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Rabbit Polyclonal TMED8 Antibody

  • 中文名: TMED8抗体
  • 别    名: Protein TMED8, TMED8, FAM15B
货号: IPDX31552
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein TMED8, TMED8, FAM15B
Entrez GeneID283578
WB Predicted band size35.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis TMED8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-182 amino acids from the Central region of human TMED8.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于TMED8抗体的模拟参考文献示例(仅供参考,实际文献需通过学术数据库验证):

1. **标题**:*TMED8 as a host factor critical for SARS-CoV-2 entry*

**作者**:Zhang L, et al.

**摘要**:本研究通过CRISPR筛选发现TMED8是新冠病毒进入宿主细胞的关键宿主蛋白,抗TMED8抗体可显著抑制病毒入侵,提示其在抗病毒治疗中的潜力。

2. **标题**:*TMED8 regulates Wnt/β-catenin signaling via protein trafficking in colorectal cancer*

**作者**:Wang Y, et al.

**摘要**:揭示了TMED8通过调控Wnt通路相关蛋白的内质网-高尔基体转运促进结直肠癌进展,使用特异性抗体证实其高表达与患者不良预后相关。

3. **标题**:*TMED8 antibody-based biomarker panel for early hepatocellular carcinoma detection*

**作者**:Chen H, et al.

**摘要**:开发了一种基于TMED8抗体的血清学检测方法,结合其他标志物可提高早期肝癌诊断灵敏度,为无创筛查提供新策略。

4. **标题**:*Structural characterization of TMED8 in ER-Golgi transport using cryo-EM*

**作者**:Kimura T, et al.

**摘要**:通过冷冻电镜解析TMED8蛋白复合体结构,抗体表位定位实验揭示了其在囊泡运输中的分子机制,为靶向运输通路研究提供依据。

**注意**:以上文献为模拟生成,实际引用需通过PubMed、Web of Science等平台核实原文信息。

背景信息

The TMED8 antibody targets Transmembrane Epidermal Growth Factor-like and Follistatin Domain-containing Protein 8 (TMED8), a member of the TMED/p24 family involved in intracellular protein trafficking and vesicular transport. TMED8 is a conserved transmembrane protein localized to the endoplasmic reticulum (ER) and Golgi apparatus, playing roles in cargo sorting, vesicle formation, and maintaining Golgi structure. Structurally, it contains a coiled-coil domain and a GOLD (Golgi dynamics) domain, enabling interactions with other trafficking machinery components. TMED8 antibodies are widely used in research to study its expression patterns, subcellular localization, and functional mechanisms, employing techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. Dysregulation of TMED8 has been implicated in diseases linked to secretory pathway defects, such as cancer progression, neurodegenerative disorders, and immune dysregulation. For example, altered TMED8 expression may disrupt protein secretion or promote oncogenic signaling. These antibodies help elucidate TMED8's role in physiological processes (e.g., cytokine secretion, receptor transport) and pathological conditions, making them valuable tools for both basic and translational studies targeting membrane trafficking pathways.

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