| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Netrin-3, Netrin-2-like protein, NTN3, NTN2L |
| Entrez GeneID | 4917 |
| WB Predicted band size | 61.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NTN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 431-459 amino acids from the C-terminal region of human NTN3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NTN3抗体的3篇代表性文献的简要概括(文献信息为模拟示例，仅供参考)：
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1. **文献名称**：*Netrin-3 (NTN3) as a novel biomarker in colorectal cancer: Development of a monoclonal antibody for detection*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种针对NTN3的新型单克隆抗体，验证了其在结直肠癌组织中的高特异性结合能力。实验表明，NTN3在肿瘤微环境中过表达，其抗体可用于免疫组化检测，提示NTN3可能作为结直肠癌诊断的潜在生物标志物。
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2. **文献名称**：*Targeting NTN3 with neutralizing antibodies inhibits tumor angiogenesis in preclinical models*
**作者**：Li X, et al.
**摘要**：通过筛选获得靶向NTN3的中和抗体，并在小鼠模型中验证其抗肿瘤效果。研究发现，阻断NTN3信号通路可显著抑制肿瘤血管生成，减缓乳腺癌和肺癌的生长，为NTN3抗体在癌症治疗中的应用提供了实验依据。
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3. **文献名称**：*NTN3 antibody-based ELISA assay for neurodegenerative disease biomarker discovery*
**作者**：Garcia R, et al.
**摘要**：利用NTN3抗体建立了一种高灵敏度的ELISA检测方法，用于定量分析脑脊液中的NTN3水平。研究发现，阿尔茨海默病患者NTN3浓度显著降低，提示其可能参与神经退行性病变的调控，并为相关疾病的早期诊断提供了新工具。
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**备注**：以上文献为示例性质，实际研究中需通过PubMed、Web of Science等平台检索真实发表的研究。若需具体文献，建议使用关键词"NTN3 antibody"或"Netrin-3 antibody"进一步筛选。
The NTN3 antibody targets Netrin-3 (NTN3), a secreted protein belonging to the netrin family of extracellular guidance molecules. Netrins play critical roles in axon guidance, cell migration, and angiogenesis during development. NTN3 shares structural homology with other netrins, including laminin-like domains, and interacts with receptors such as DCC (Deleted in Colorectal Cancer) and UNC5 family members to mediate chemotropic signaling. While NTN1 and NTN4 are more extensively studied, NTN3 has gained attention for its potential involvement in cancer progression, neurodevelopmental disorders, and inflammatory diseases.
NTN3 antibodies are primarily used in research to detect endogenous NTN3 expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry, or immunofluorescence. They help elucidate NTN3's spatial distribution and dynamic expression patterns during development or disease states. Recent studies suggest NTN3 may regulate tumor cell proliferation, metastasis, and immune evasion in certain cancers, making it a potential therapeutic target. Additionally, NTN3 antibodies are employed to study its role in neuronal connectivity and repair mechanisms, particularly in contexts of spinal cord injury or neurodegeneration. Commercial NTN3 antibodies are typically validated for specificity, often through knockout cell line controls, and may vary in reactivity across species. Ongoing research aims to clarify NTN3's dual functions as a chemoattractant or repellent, depending on receptor context and microenvironmental cues.
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