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Rabbit Polyclonal PAQR8 Antibody

  • 中文名： PAQR8抗体
  • 别    名： Membrane progestin receptor beta, mPR beta, Lysosomal membrane protein in brain 1, Progestin and adipoQ receptor family member 8, Progestin and adipoQ receptor family member VIII, PAQR8, C6orf33, LMPB1, MPRB
货号: IPDX31543
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMembrane progestin receptor beta, mPR beta, Lysosomal membrane protein in brain 1, Progestin and adipoQ receptor family member 8, Progestin and adipoQ receptor family member VIII, PAQR8, C6orf33, LMPB1, MPRB
Entrez GeneID85315
WB Predicted band size40.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis PAQR8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-354 amino acids from the C-terminal region of human PAQR8.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PAQR8抗体的3篇代表性文献及其摘要概括：

1. **文献名称**：*"PAQR8 regulates adipogenesis and systemic glucose metabolism through a novel adipocyte-specific signaling pathway"*

**作者**：Tang T, et al.

**摘要**：研究揭示了PAQR8在脂肪细胞分化和糖代谢中的关键作用，通过开发特异性PAQR8抗体验证其在脂肪组织中的蛋白表达，并证明其缺失导致胰岛素抵抗和代谢紊乱。

2. **文献名称**：*"Characterization of PAQR family receptors and their antibodies in cellular membrane localization"*

**作者**：Li Y, et al.

**摘要**：该研究针对PAQR家族受体(包括PAQR8)的亚细胞定位展开，利用定制多克隆抗体进行免疫荧光和Western blot分析，证实PAQR8主要定位于细胞膜，参与脂质信号转导。

3. **文献名称**：*"Antibody-based detection of PAQR8 in cardiovascular disease models"*

**作者**：Zhang H, et al.

**摘要**：通过构建PAQR8特异性单克隆抗体，研究其在动脉粥样硬化模型中的表达变化，发现PAQR8蛋白水平与血管炎症指标呈负相关，提示其潜在治疗靶点价值。

注：以上文献信息为基于领域知识的模拟示例，实际引用需通过PubMed或专业数据库核实具体研究。

背景信息

The PAQR8 antibody is a research tool designed to target Progestin and AdipoQ Receptor 8 (PAQR8), a member of the PAQR family of membrane-bound receptors. PAQR8. also known as membrane progestin receptor beta (mPRβ), is a seven-transmembrane protein implicated in mediating rapid, non-genomic signaling responses to progesterone and other ligands. It is structurally distinct from classical nuclear steroid receptors and is thought to play roles in reproductive physiology, neuroprotection, and metabolic regulation. PAQR8 is expressed in various tissues, including the brain, ovaries, and adipose tissue, suggesting diverse functional roles. The PAQR8 antibody is primarily used in experimental applications such as Western blotting, immunohistochemistry, and immunofluorescence to detect and localize PAQR8 protein expression in biological samples. Its development has facilitated investigations into PAQR8's involvement in cellular processes like apoptosis, inflammation, and hormone signaling. Recent studies highlight its potential relevance in cancer progression, metabolic disorders, and neurological diseases, though mechanistic details remain under exploration. Commercial PAQR8 antibodies are typically validated for specificity using knockout controls or siRNA-mediated silencing. Researchers utilize these tools to elucidate PAQR8's physiological and pathological roles, aiding drug discovery and biomarker identification for related diseases.

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