| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Proprotein convertase subtilisin/kexin type 6, 3421-, Paired basic amino acid cleaving enzyme 4, Subtilisin-like proprotein convertase 4, SPC4, Subtilisin/kexin-like protease PACE4, PCSK6, PACE4 |
| Entrez GeneID | 5046 |
| WB Predicted band size | 106.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PCSK6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 659-688 amino acids from the C-terminal region of human PCSK6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下为3篇与PCSK6抗体相关的示例文献(内容为模拟概括，建议通过学术数据库核实具体信息)：
1. **文献名称**: "PCSK6-mediated proprotein convertase activity in ovarian cancer progression"
**作者**: Mathieu, R. et al.
**摘要**: 研究报道了PCSK6在卵巢癌细胞中的高表达，通过特异性抗体检测发现其通过激活TGF-β通路促进肿瘤侵袭，提示其作为潜在治疗靶点。
2. **文献名称**: "PCSK6 regulates blood pressure through proteolytic processing of renal ENaC subunits"
**作者**: Baudry, J. & Seidah, N.G.
**摘要**: 利用PCSK6抗体在小鼠模型中发现，PCSK6通过切割上皮钠通道(ENaC)调控钠离子重吸收，其表达异常与高血压相关。
3. **文献名称**: "Autoantibodies against PCSK6 in polycystic ovary syndrome"
**作者**: Mishra, S. et al.
**摘要**: 研究通过ELISA和免疫印迹法检测到PCOS患者血清中存在抗PCSK6自身抗体，可能与激素代谢紊乱及胰岛素抵抗相关。
4. **文献名称**: "Proprotein convertases in development and disease"
**作者**: Seidah, N.G. & Chrétien, M.
**摘要**: 综述类文章，涵盖PCSK6在内的前蛋白转化酶家族功能，提及抗体工具在解析其组织分布及疾病机制中的应用。
注：以上文献名为示例概括，实际研究需通过PubMed或Google Scholar检索关键词(如"PCSK6 antibody" "proprotein convertase 6")获取具体文献。
**Background of PCSK6 Antibodies**
PCSK6 (proprotein convertase subtilisin/kexin type 6), also known as PACEd4. is a member of the proprotein convertase family, which processes precursor proteins into bioactive forms by cleaving specific peptide bonds. Primarily expressed in tissues like the heart, placenta, and certain tumors, PCSK6 plays roles in embryogenesis, extracellular matrix remodeling, and activation of growth factors (e.g., TGF-β) or enzymes (e.g., matrix metalloproteinases). Dysregulation of PCSK6 is implicated in cancers, cardiovascular diseases, and autoimmune disorders, where it may promote tumor progression, metastasis, or vascular abnormalities.
Antibodies targeting PCSK6 are essential tools for studying its expression, localization, and function. In research, monoclonal or polyclonal PCSK6 antibodies are used in techniques like Western blotting, immunohistochemistry, or ELISA to quantify protein levels or map tissue distribution. Clinically, autoantibodies against PCSK6 have been explored in autoimmune conditions, potentially linked to disrupted protein processing or immune dysregulation. Additionally, therapeutic antibodies inhibiting PCSK6 activity are under investigation for diseases driven by excessive proteolytic processing. However, the pathophysiological roles of PCSK6 and its antibodies remain incompletely understood, necessitating further studies to clarify their diagnostic or therapeutic potential.
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