| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Linker for activation of T-cells family member 2, Linker for activation of B-cells, Membrane-associated adapter molecule, Non-T-cell activation linker, Williams-Beuren syndrome chromosomal region 15 protein, Williams-Beuren syndrome chromosomal region 5 protein, LAT2, LAB, NTAL, WBS15, WBSCR15, WBSCR5 |
| Entrez GeneID | 7462 |
| WB Predicted band size | 26.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-135 amino acids from the Central region of human LAT2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于LAT2抗体的3篇示例文献(注：文献信息为模拟概括，具体文献需通过学术数据库查询验证)：
---
1. **标题**：*LAT2 (SLC7A8) expression in renal proximal tubules: Role in amino acid reabsorption*
**作者**：Fukushima K, et al.
**摘要**：通过抗LAT2抗体的免疫组化和Western blot分析，研究发现LAT2在小鼠肾脏近端小管细胞顶膜高表达，参与中性氨基酸转运，并受饮食中蛋白质含量的调节，提示其在肾脏氨基酸代谢中的关键作用。
2. **标题**：*Differential expression of LAT2 in colorectal cancer and its association with tumor progression*
**作者**：Chen L, et al.
**摘要**：利用LAT2特异性抗体对结直肠癌组织进行免疫染色，发现LAT2在肿瘤细胞中显著上调，与患者生存率负相关，可能通过促进癌细胞摄取必需氨基酸驱动肿瘤生长。
3. **标题**：*LAT2-mediated amino acid transport supports glioblastoma cell proliferation*
**作者**：Pochini L, et al.
**摘要**：研究通过LAT2抗体阻断实验和siRNA敲低，证实胶质母细胞瘤细胞依赖LAT2转运亮氨酸等中性氨基酸，抑制LAT2可降低mTORC1信号通路活性并抑制肿瘤细胞增殖。
---
**建议**：如需具体文献，可通过PubMed或Google Scholar以关键词“LAT2 antibody”“SLC7A8”“amino acid transporter”检索，并筛选涉及抗体应用的研究(如免疫组化、Western blot或功能阻断实验)。
LAT2 (L-type amino acid transporter 2), also known as SLC7A8. is a sodium-independent neutral amino acid transporter belonging to the SLC7 solute carrier family. It forms a heterodimeric complex with CD98 (SLC3A2) to facilitate the transport of essential amino acids like leucine, isoleucine, and phenylalanine across cell membranes. LAT2 is widely expressed in tissues, including the kidney, intestine, placenta, and brain, and plays a critical role in cellular nutrient sensing, protein synthesis, and metabolic regulation.
Research highlights LAT2's involvement in cancer progression, as many tumors upregulate LAT2 to meet increased amino acid demands for rapid proliferation. Its activity is linked to mTOR signaling, a key pathway in cell growth and survival. LAT2 antibodies are essential tools for studying its expression patterns, subcellular localization, and functional roles in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to investigate LAT2's association with tumor metabolism, drug resistance, and potential as a therapeutic target. Commercially available LAT2 antibodies are typically raised against specific epitopes of human or murine LAT2 proteins. Validation for specificity and cross-reactivity is crucial due to structural similarities within the SLC7 family. Emerging studies also explore LAT2's role in neurological and metabolic disorders, expanding its biomedical relevance.
×
