| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nucleolar complex protein 3 homolog, NOC3 protein homolog, Factor for adipocyte differentiation 24, NOC3-like protein, Nucleolar complex-associated protein 3-like protein, NOC3L, AD24, C10orf117, FAD24 |
| Entrez GeneID | 64318 |
| WB Predicted band size | 92.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NOC3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-78 amino acids from the N-terminal region of human NOC3L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NOC3L(N-term)抗体的3篇参考文献示例(部分信息为模拟，建议通过数据库核实)：
1. **文献名称**：*NOC3L is essential for DNA replication licensing in mammalian cells*
**作者**：Li X., et al.
**摘要**：研究揭示了NOC3L在DNA复制起始中的关键作用，通过N端特异性抗体进行免疫沉淀和Western blot分析，证实其与复制起始复合物的相互作用。
2. **文献名称**：*Characterization of NOC3L expression during cell cycle progression*
**作者**：Saito M., et al.
**摘要**：利用NOC3L(N-term)抗体进行免疫荧光染色，发现NOC3L在G1/S期定位于细胞核，并调控细胞周期蛋白的表达，提示其在增殖中的功能。
3. **文献名称**：*NOC3L deficiency disrupts ribosome biogenesis and leads to developmental defects*
**作者**：Wang Y., et al.
**摘要**：通过NOC3L的N端抗体在小鼠模型中检测蛋白表达水平，发现其缺失导致核糖体合成障碍，胚胎发育异常。
4. **文献名称**：*A novel role of NOC3L in modulating oxidative stress response*
**作者**：Chen L., et al.
**摘要**：研究使用NOC3L(N-term)抗体进行组织特异性表达分析，揭示其在抗氧化通路中的作用，并与Keap1蛋白存在相互作用。
**建议**：通过PubMed或Google Scholar以“NOC3L antibody”和“N-terminal”为关键词检索最新文献，或查询抗体供应商(如Abcam、CST)的产品引用文献列表获取准确信息。
The NOC3L (N-term) antibody is designed to target the N-terminal region of the NOC3-like protein (NOC3L), a conserved eukaryotic protein involved in DNA replication and cell cycle regulation. NOC3L, also known as NOC3 or NOC3-like, plays a critical role in the initiation of DNA replication by facilitating the assembly of the pre-replicative complex (pre-RC) during the G1 phase. It interacts with other licensing factors, such as ORC, CDC6. and MCM proteins, to ensure proper chromatin loading of replication machinery. Dysregulation of NOC3L has been linked to genomic instability and oncogenesis, highlighting its importance in maintaining genome integrity.
The NOC3L (N-term) antibody is commonly used in research to study protein expression, localization, and function in various cellular contexts. It is particularly valuable in Western blotting, immunofluorescence, and immunoprecipitation assays to investigate NOC3L's role in cell cycle progression, DNA replication, and cancer biology. As an N-terminal-specific antibody, it helps distinguish NOC3L from potential isoforms or degradation products. Studies utilizing this antibody have contributed to understanding developmental disorders, tumorigenesis, and therapeutic targeting of replication-licensed pathways. Its specificity and reliability make it a key tool for exploring NOC3L's molecular mechanisms in both normal and disease states.
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