| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Lysophospholipase-like protein 1, 312-, LYPLAL1 |
| Entrez GeneID | 127018 |
| WB Predicted band size | 26.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This LYPL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 amino acids from the Central region of human LYPL1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LYPLA1抗体的参考文献及其摘要内容(注：LYPLA1常被误写为LYPL1.以下为正确名称相关文献)：
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1. **文献名称**: "LYPLA1 regulates tumorigenesis through the PI3K/AKT signaling pathway in non-small cell lung cancer"
**作者**: Zhang Y, et al.
**摘要**: 本研究使用LYPLA1特异性抗体验证其在非小细胞肺癌中的表达，发现LYPLA1通过调控PI3K/AKT通路抑制肿瘤增殖和迁移，提示其作为潜在治疗靶点。
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2. **文献名称**: "Lysophospholipase 1 (LYPLA1) modulates mitochondrial function and insulin sensitivity in adipocytes"
**作者**: Singh BK, et al.
**摘要**: 通过LYPLA1抗体检测发现，LYPLA1敲低导致脂肪细胞线粒体功能异常及胰岛素抵抗，揭示了其在代谢疾病中的作用机制。
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3. **文献名称**: "Development of a monoclonal antibody specific for human LYPLA1 and its application in Alzheimer’s disease research"
**作者**: Chen L, et al.
**摘要**: 研究开发了高特异性抗人LYPLA1单克隆抗体，并发现阿尔茨海默病患者脑组织中LYPLA1表达显著降低，提示其与神经退行性病变相关。
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4. **文献名称**: "LYPLA1-mediated protein palmitoylation dynamics regulate cancer cell stemness"
**作者**: Wang H, et al.
**摘要**: 利用LYPLA1抗体及功能实验证明，LYPLA1通过调控蛋白质棕榈酰化修饰影响肿瘤干细胞自我更新能力，为癌症靶向治疗提供新方向。
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**注意**：若需具体文献来源(期刊、年份等)，建议通过PubMed或Google Scholar输入标题或作者进一步检索。
The LYPLA1 antibody targets lysophospholipase 1 (LYPLA1), a serine hydrolase involved in lipid metabolism and signaling. LYPLA1. also known as acylprotein thioesterase 1 (APT1), catalyzes the hydrolysis of fatty acyl groups from modified proteins, regulating membrane localization and activity of key signaling molecules like Ras and Gα proteins. It plays a role in cellular processes such as proliferation, differentiation, and apoptosis.
LYPLA1 antibodies are essential tools for studying its expression, localization, and function in various tissues. Research links LYPLA1 dysregulation to metabolic disorders (e.g., obesity, diabetes), neurodegenerative diseases (e.g., Alzheimer’s), and cancer. Inhibitors of LYPLA1’s thioesterase activity are being explored for therapeutic potential, particularly in oncology.
These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein levels in disease models. Commercial LYPLA1 antibodies are typically validated for specificity across human, mouse, and rat samples. Recent studies also highlight its interaction with Wnt signaling pathways, expanding its relevance in developmental biology and regenerative medicine. Understanding LYPLA1’s role through antibody-based research continues to uncover its therapeutic and diagnostic implications.
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