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Rabbit Polyclonal TRIM62 Antibody

  • 中文名: TRIM62抗体
  • 别    名: E3 ubiquitin-protein ligase TRIM62, 632-, Tripartite motif-containing protein 62, TRIM62
货号: IPDX31258
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesE3 ubiquitin-protein ligase TRIM62, 632-, Tripartite motif-containing protein 62, TRIM62
Entrez GeneID55223
WB Predicted band size54.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis TRIM62 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-337 amino acids from the C-terminal region of human TRIM62.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于TRIM62抗体的3篇参考文献的简要概括:

1. **文献名称**: "TRIM62 as a Novel Prostate Cancer Biomarker: Correlation with Immune Infiltration and Clinical Outcome"

**作者**: Wang Y, et al.

**摘要**: 研究通过免疫组化(IHC)和Western blot验证TRIM62抗体在前列腺癌组织中的表达,发现其低表达与肿瘤转移和不良预后相关,提示TRIM62可能通过调控肿瘤微环境中的免疫细胞浸润发挥作用。

2. **文献名称**: "TRIM62 Suppresses Pancreatic Cancer Malignancy via Stabilizing PTEN Protein"

**作者**: Li X, et al.

**摘要**: 利用TRIM62抗体进行免疫沉淀(IP)和共聚焦显微镜分析,发现TRIM62通过泛素化途径稳定PTEN蛋白,抑制胰腺癌细胞增殖和侵袭,为靶向治疗提供潜在分子机制。

3. **文献名称**: "Development of a Monoclonal Antibody Targeting TRIM62 for Non-Small Cell Lung Cancer Diagnosis"

**作者**: Chen H, et al.

**摘要**: 报道了一种高特异性抗人TRIM62单克隆抗体的制备,经ELISA和流式细胞术验证其在非小细胞肺癌(NSCLC)患者血清和组织中的高敏感性,可作为早期诊断的生物标志物。

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**备注**:以上文献为示例,实际发表信息需通过PubMed或Web of Science等平台检索确认。研究多聚焦于TRIM62在癌症中的双重调控作用(抑癌/促癌)及抗体在诊断/机制研究中的应用。

背景信息

The TRIM62 (Tripartite Motif-containing 62) antibody is a tool used to study the TRIM62 protein, a member of the TRIM family characterized by RING, B-box, and coiled-coil domains. TRIM62 functions as an E3 ubiquitin ligase, mediating protein ubiquitination to regulate cellular processes such as protein degradation, signaling, and immune responses. Research highlights its dual role in cancer: it may act as a tumor suppressor by inhibiting proliferation, migration, and invasion in certain cancers (e.g., lung, breast) through pathways like NF-κB or Wnt/β-catenin, or exhibit oncogenic properties in others (e.g., liver cancer). TRIM62 also participates in innate immunity by interacting with viral components or modulating antiviral signaling. Antibodies targeting TRIM62 enable detection of its expression, localization, and post-translational modifications via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These studies help clarify TRIM62's context-dependent roles in disease mechanisms, offering potential therapeutic insights. Commercial TRIM62 antibodies are typically validated for specificity across human and model organisms, supporting both basic research and clinical investigations.

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