| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Proline-rich protein 15-like protein, Protein ATAD4, PRR15L, ATAD4 |
| Entrez GeneID | 79170 |
| WB Predicted band size | 11.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ATAD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-103 amino acids from the C-terminal region of human ATAD4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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The ATAD4 (ATPase family AAA domain-containing protein 4) antibody is a tool used to study the ATAD4 protein, a member of the AAA+ ATPase family involved in chromatin remodeling, DNA replication, and epigenetic regulation. ATAD4 plays a critical role in replication stress response by interacting with the ATR kinase pathway and facilitating DNA repair. It is also linked to histone acetylation dynamics through its association with histone acetyltransferases like HBO1. impacting gene expression and cellular differentiation. Dysregulation of ATAD4 has been implicated in cancer, particularly in promoting genomic instability and tumor progression, making it a potential biomarker or therapeutic target.
ATAD4 antibodies are widely used in research to detect protein expression, localization, and interactions via techniques such as Western blotting, immunofluorescence, and immunohistochemistry. These antibodies are essential for investigating ATAD4’s role in oncogenesis, stem cell biology, and epigenetic mechanisms. Validated antibodies are critical to ensure specificity, as cross-reactivity with other AAA+ proteins can occur. Commercial ATAD4 antibodies are typically raised in rabbits or mice, with clones verified using knockout cell lines or peptide-blocking assays. Studies employing ATAD4 antibodies have advanced understanding of its dual roles in maintaining genomic integrity and regulating chromatin structure, highlighting its therapeutic relevance in diseases like cancer.
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