| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cadherin-22, Pituitary and brain cadherin, PB-cadherin, CDH22, C20orf25 |
| Entrez GeneID | 64405 |
| WB Predicted band size | 89.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CDH22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 411-440 amino acids from the Central region of human CDH22. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CDH22抗体的3篇参考文献示例(内容为模拟概括，具体文献需根据实际数据库查询)：
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1. **文献名称**：*CDH22 as a potential therapeutic target in gastric cancer: Antibody development and functional analysis*
**作者**：Li Y, et al.
**摘要**：研究开发了针对CDH22的单克隆抗体，并验证其在胃癌组织中的高表达特性。实验表明，该抗体可通过阻断CDH22介导的细胞粘附通路抑制肿瘤细胞迁移，提示其在胃癌靶向治疗中的潜力。
2. **文献名称**：*Structural characterization of CDH22 extracellular domain and its application in antibody design*
**作者**：Smith J, et al.
**摘要**：通过X射线晶体学解析了CDH22胞外域的三维结构，并基于此设计出高亲和力抗体。该抗体在小鼠模型中显示出对CDH22过表达肿瘤的特异性靶向作用，为开发诊断试剂奠定基础。
3. **文献名称**：*CDH22 expression in neurodegenerative disorders: A novel biomarker identified by immunohistochemical analysis*
**作者**：Wang X, et al.
**摘要**：利用CDH22抗体对阿尔茨海默病脑组织进行免疫组化分析，发现CDH22在神经元突触区域的异常聚集与疾病进展相关，提示其可能作为神经退行性病变的生物标志物。
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如需具体文献，建议通过PubMed或Google Scholar以“CDH22 antibody”为关键词检索近年研究。
CDH22 antibody targets cadherin-22 (CDH22), a member of the cadherin superfamily of calcium-dependent cell adhesion proteins. Cadherins play critical roles in tissue morphogenesis, cell-cell recognition, and signal transduction. CDH22. encoded by the *CDH22* gene, is a type II classical cadherin characterized by extracellular cadherin repeats, a transmembrane domain, and a cytoplasmic tail that interacts with catenins to link the cytoskeleton. While its exact physiological functions remain less defined compared to other cadherins, CDH22 is implicated in neuronal development, synaptic plasticity, and cancer progression. Studies suggest it may regulate cell migration, adhesion, and tissue organization in context-dependent manners.
CDH22 antibodies are primarily used as research tools to investigate protein expression, localization, and functional roles in vitro and in vivo. In cancer research, CDH22 has shown dual roles: some studies report its upregulation in malignancies like glioblastoma and colorectal cancer, associating it with invasiveness, while others note tumor-suppressive effects in certain contexts. In neuroscience, CDH22 is linked to axon guidance and synaptic connectivity, though mechanistic insights are limited. Commercial CDH22 antibodies are typically validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence, though variability in specificity remains a challenge. Ongoing research aims to clarify CDH22's signaling pathways, interactions, and therapeutic potential, particularly in diseases with cadherin dysregulation.
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