首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal NDST1 Antibody

  • 中文名： NDST1抗体
  • 别    名： Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1, Glucosaminyl N-deacetylase/N-sulfotransferase 1, NDST-1, N-heparan sulfate sulfotransferase 1, N-HSST 1, [Heparan sulfate]-glucosamine N-sulfotransferase 1, HSNST 1, Heparan sulfate N-deacet
货号: IPDX31245
Price： ￥1180
数量：
大包装询价

验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesBifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1, Glucosaminyl N-deacetylase/N-sulfotransferase 1, NDST-1, N-heparan sulfate sulfotransferase 1, N-HSST 1, [Heparan sulfate]-glucosamine N-sulfotransferase 1, HSNST 1, Heparan sulfate N-deacetylase 1, 3---, Heparan sulfate N-sulfotransferase 1, 282-, NDST1, HSST, HSST1
Entrez GeneID3340
WB Predicted band size100.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis NDST1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 820-849 amino acids from the C-terminal region of human NDST1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是3篇与NDST1抗体相关的文献摘要概括(基于公开文献模拟，非真实引用)：

---

1. **文献名称**: *"NDST1 regulates vascular development through sulfation of heparan sulfate in zebrafish"*

**作者**: Chen E. et al.

**摘要**: 本研究利用NDST1特异性抗体进行免疫荧光和Western blot分析，发现斑马鱼胚胎中NDST1通过硫酸化修饰调控血管内皮生长因子(VEGF)信号通路，揭示了其在血管生成中的关键作用。

---

2. **文献名称**: *"Impaired NDST1 expression alters heparan sulfate structure and promotes tumor metastasis in murine models"*

**作者**: Zhang L. et al.

**摘要**: 通过NDST1抗体检测小鼠肿瘤模型中NDST1蛋白表达水平，发现NDST1缺失导致硫酸乙酰肝素结构异常，进而增强肿瘤细胞侵袭能力，为癌症治疗提供了潜在靶点。

---

3. **文献名称**: *"NDST1 deficiency disrupts neuronal migration in developing mouse brain"*

**作者**: Smith J.R. et al.

**摘要**: 采用NDST1抗体进行脑组织免疫组化分析，发现NDST1敲除小鼠的皮质神经元迁移受阻，表明其通过调节细胞外基质影响神经发育过程。

---

4. **文献名称**: *"Antibody-based profiling of NDST1 isoforms in human tissues reveals differential expression patterns"*

**作者**: Kim H. et al.

**摘要**: 开发了一种高特异性NDST1抗体，用于分析不同人类组织(如肝、肾、脑)中NDST1亚型的表达差异，为组织特异性硫酸乙酰肝素功能研究提供工具。

---

注：以上文献信息为模拟生成，实际研究请通过PubMed或Web of Science等数据库检索真实文献。

背景信息

The NDST1 (N-deacetylase/N-sulfotransferase 1) antibody is a tool used to study the enzyme critical for heparan sulfate (HS) biosynthesis. NDST1. a member of the NDST family, catalyzes the dual-modification of heparan sulfate precursors by removing acetyl groups (deacetylation) and adding sulfate groups (sulfation) to specific glucosamine residues. This process is essential for generating the structural diversity of heparan sulfate, a glycosaminoglycan involved in cell signaling, extracellular matrix organization, and molecular interactions. NDST1 is widely expressed in tissues, with pivotal roles in embryonic development, angiogenesis, and neural circuit formation. Dysregulation of NDST1 has been linked to pathologies, including cancer, inflammation, and developmental disorders. Antibodies targeting NDST1 enable researchers to detect and quantify protein expression via techniques like Western blotting, immunohistochemistry, or immunofluorescence. They are particularly valuable in studying HS-dependent processes, such as growth factor signaling (e.g., FGF, VEGF), cell adhesion, and pathogen invasion. Recent studies also explore NDST1's involvement in tumor microenvironment modulation and its potential as a therapeutic target. Validation of NDST1 antibodies includes specificity checks using knockout controls and functional assays to correlate expression with enzymatic activity.

客户数据及评论

折叠内容

大包装询价

×