| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Carboxypeptidase N subunit 2, Carboxypeptidase N 83 kDa chain, Carboxypeptidase N large subunit, Carboxypeptidase N polypeptide 2, Carboxypeptidase N regulatory subunit, CPN2, ACBP |
| Entrez GeneID | 1370 |
| WB Predicted band size | 60.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CPN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human CPN2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CPN2(N-term)抗体的模拟参考文献示例(仅供参考，非真实文献)：
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1. **文献名称**：*Characterization of a Novel N-terminal Specific Antibody for Carboxypeptidase N Subunit 2 (CPN2) in Human Plasma*
**作者**：Zhang L, et al.
**摘要**：本研究开发了一种针对CPN2蛋白N端表位的兔源多克隆抗体，通过ELISA和Western blot验证其特异性。该抗体成功应用于检测人血浆中CPN2的浓度，并揭示了其在炎症性疾病中的潜在生物标志物作用。
2. **文献名称**：*CPN2 N-terminal Antibody Application in Immunohistochemical Analysis of Renal Tissues*
**作者**：Tanaka K, et al.
**摘要**：文章报道了一种抗CPN2 N端区域的小鼠单克隆抗体的制备，并通过免疫组化技术证实其在肾组织切片中的定位能力。研究发现CPN2在糖尿病肾病患者的肾小球中表达显著上调。
3. **文献名称**：*Functional Role of CPN2 in Complement Regulation: Insights from Antibody-Mediated Knockdown*
**作者**：Müller R, et al.
**摘要**：利用针对CPN2 N端的特异性抗体，研究者通过免疫沉淀和功能实验证明CPN2在补体系统调控中的关键作用。抗体阻断实验显示CPN2缺失会增强补体激活途径的活性。
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**注意**：以上文献为模拟内容，实际研究中请通过**PubMed**或**Google Scholar**以关键词“CPN2 antibody N-terminal”或“Carboxypeptidase N subunit 2 antibody”检索真实文献。建议结合具体实验需求(如物种、应用场景)筛选抗体相关研究。
The CPN2 (N-term) antibody is designed to target the amino-terminal region of Carboxypeptidase N subunit 2 (CPN2), a critical component of the Carboxypeptidase N (CPN) enzyme complex. CPN, also known as kininase I or anaphylatoxin inactivator, is a zinc-dependent metalloprotease primarily synthesized in the liver and secreted into the bloodstream. It consists of two subunits: an 82 kDa catalytic subunit (CPN1) and a 55 kDa protective glycoprotein subunit (CPN2). CPN2 stabilizes CPN1. prolonging its enzymatic activity in circulation by shielding it from degradation or inhibition.
CPN plays a key role in regulating bioactive peptides, including inactivating inflammatory mediators like kinins (e.g., bradykinin) and anaphylatoxins (e.g., C3a, C5a). Dysregulation of CPN activity is linked to conditions such as hereditary angioedema, sepsis, and inflammatory disorders. The N-terminal region of CPN2 is essential for its interaction with CPN1 and overall complex stability. Antibodies targeting this region, such as CPN2 (N-term), are valuable tools for studying CPN2 expression, protein-protein interactions, and functional roles in physiological or pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to investigate CPN's involvement in immune regulation, vascular permeability, and potential therapeutic targeting.
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