| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Sodium/calcium exchanger 3, Na(+)/Ca(2+)-exchange protein 3, Solute carrier family 8 member 3, SLC8A3, NCX3 |
| Entrez GeneID | 6547 |
| WB Predicted band size | 103.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SLC8A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 585-614 amino acids of human SLC8A3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于SLC8A3(NCX3)抗体的假设性参考文献示例(注：文献为示例性质，非真实存在)：
1. **文献名称**: "Role of NCX3 in neuronal calcium homeostasis during ischemic injury"
**作者**: Storck, E.M. et al.
**摘要**: 研究利用SLC8A3特异性抗体，通过免疫印迹和免疫荧光技术，揭示了NCX3在缺血性脑损伤中通过调节神经元钙外流发挥神经保护作用，抗体验证了其在海马体中的高表达。
2. **文献名称**: "Localization of SLC8A3 in retinal neurons using a novel monoclonal antibody"
**作者**: Castañeyra-Ruiz, L. et al.
**摘要**: 开发了一种高特异性抗SLC8A3单克隆抗体，通过免疫组化证实NCX3在视网膜双极细胞中的定位，表明其参与视觉信号传递中的钙动态平衡。
3. **文献名称**: "SLC8A3 expression correlates with muscle fatigue resistance in aging"
**作者**: Guerini, D. et al.
**摘要**: 使用SLC8A3抗体分析骨骼肌样本，发现老年个体中NCX3蛋白水平下降与肌浆网钙清除能力降低相关，提示其在延缓肌肉衰老中的潜在作用。
4. **文献名称**: "Antibody-based validation of NCX3 isoforms in cancer cell lines"
**作者**: Khananshvili, R. et al.
**摘要**: 通过多克隆SLC8A3抗体鉴定了NCX3的两种剪接变体，揭示其在癌细胞钙信号异常中的异构体特异性功能差异。
(注：以上文献为示例，实际文献需通过PubMed/Google Scholar等平台以关键词"SLC8A3 antibody"或"NCX3 antibody"检索确认。)
The solute carrier family 8 member 3 (SLC8A3), also known as the sodium-calcium exchanger 3 (NCX3), is a transmembrane protein that mediates the bidirectional exchange of Na⁺ and Ca²⁺ ions across cellular membranes. It plays a critical role in maintaining calcium homeostasis, particularly in excitable tissues such as neurons, skeletal muscle, and cardiac cells. NCX3 is involved in regulating intracellular calcium levels during cellular processes like neurotransmission, muscle contraction, and apoptosis. Dysregulation of NCX3 has been implicated in neurological disorders, cardiovascular diseases, and cancer.
SLC8A3 antibodies are immunological tools designed to detect and quantify the expression of the NCX3 protein in research applications. These antibodies are commonly produced in hosts such as rabbits or mice using immunogenic peptides derived from conserved regions of the human or rodent NCX3 protein. They are widely utilized in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to study NCX3 localization, expression patterns, and functional roles in physiological and pathological contexts. Validation of SLC8A3 antibodies typically involves knockout controls or siRNA-mediated knockdown to ensure specificity. Researchers employ these antibodies to explore NCX3's involvement in calcium signaling pathways, its interaction with other ion transporters, and its potential as a therapeutic target in diseases associated with calcium dysregulation. Commercial SLC8A3 antibodies often cite applications in neurodegenerative disease models, cardiac hypertrophy studies, and cancer cell migration assays.
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