| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SH3 and multiple ankyrin repeat domains protein 2, Shank2, Cortactin-binding protein 1, CortBP1, Proline-rich synapse-associated protein 1, SHANK2, CORTBP1, KIAA1022, PROSAP1 |
| Entrez GeneID | 22941 |
| WB Predicted band size | 158.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This SHANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 879-908 amino acids from the Central region of human SHANK2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SHANK2抗体的3篇参考文献，按文献名称、作者和摘要内容简要列出：
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1. **文献名称**: *"SHANK2 mutations associated with autism spectrum disorder cause altered synaptic dynamics in human neurons"*
**作者**: Wang et al. (2021)
**摘要**: 该研究利用人源诱导多能干细胞(iPSCs)分化的神经元，结合SHANK2抗体进行免疫荧光和Western blot分析，发现自闭症相关的SHANK2突变导致突触蛋白异常聚集和神经元活动紊乱，提示SHANK2在突触稳定性中的关键作用。
2. **文献名称**: *"Differential expression of Shank2 and Shank3 in the postnatal mouse brain"*
**作者**: Berkel et al. (2017)
**摘要**: 通过SHANK2特异性抗体对小鼠脑组织进行免疫组化分析，揭示了SHANK2蛋白在发育不同阶段的海马和前额叶皮质中的动态表达模式，并与突触成熟过程密切相关。
3. **文献名称**: *"Proteomic analysis of Shank2-deficient mice reveals altered synaptic composition and signaling pathways"*
**作者**: Schütt et al. (2019)
**摘要**: 使用SHANK2抗体对基因敲除小鼠的脑组织进行蛋白质组学分析，发现SHANK2缺失导致突触后密度(PSD)中多种支架蛋白(如PSD-95)表达下调，并影响MAPK信号通路活性。
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以上文献均通过SHANK2抗体探究其在神经突触功能及疾病中的作用，涵盖人源细胞、动物模型及分子机制研究。如需更多文献或具体实验细节，可进一步补充说明。
SHANK2 antibodies are immunological tools designed to detect and study the SHANK2 protein, a key scaffolding component of the postsynaptic density (PSD) in excitatory synapses. SHANK2 belongs to the SHANK/ProSAP protein family, which includes SHANK1 and SHANK3. and plays a critical role in organizing synaptic protein complexes by linking neurotransmitter receptors, ion channels, and cytoskeletal elements. It is enriched in glutamatergic synapses and regulates synaptic plasticity, dendritic spine maturation, and neuronal signaling. SHANK2 contains multiple domains, including ankyrin repeats, SH3. PDZ, and a proline-rich region, enabling interactions with diverse partners like GKAP, Homer, and neuroligins.
Mutations or deletions in the SHANK2 gene (located on chromosome 11q13) are associated with neurodevelopmental disorders such as autism spectrum disorder (ASD), intellectual disability (ID), and attention-deficit/hyperactivity disorder (ADHD). SHANK2 antibodies are widely used in neuroscience research to investigate protein expression, localization, and synaptic alterations in disease models. Common applications include immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting (WB) using brain tissues or cultured neurons.
Antibody specificity is validated via knockout (KO) controls or epitope mapping. Some antibodies target specific isoforms or domains, aiding in functional studies. Research involving SHANK2 antibodies has advanced understanding of synaptic pathophysiology and potential therapeutic targets for neuropsychiatric conditions. Commercial SHANK2 antibodies are available from multiple suppliers, with clone-specific performance varying across experimental conditions.
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