| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cornifin-A, 19 kDa pancornulin, SPRK, Small proline-rich protein IA, SPR-IA, SPRR1A |
| Entrez GeneID | 6698 |
| WB Predicted band size | 9.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SPRR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-89 amino acids from the C-terminal region of human SPRR1A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SPRR1A抗体的3篇参考文献的简单摘要整理：
1. **文献名称**：Small proline-rich protein 1A (SPRR1A) is a marker for keratinocyte differentiation
**作者**：Cabral A. et al.
**摘要**：研究利用SPRR1A抗体验证其在皮肤上皮细胞分化中的表达，发现SPRR1A在表皮角质层特异高表达，提示其在屏障功能中的作用。
2. **文献名称**：SPRR1A expression in esophageal squamous cell carcinoma progression
**作者**：Zhang L. et al.
**摘要**：通过免疫组化(SPRR1A抗体)分析发现，SPRR1A在食管鳞癌组织中表达上调，与肿瘤侵袭和患者预后不良相关。
3. **文献名称**：SPRR1A interacts with desmosomal proteins in epidermal integrity maintenance
**作者**：Hsu C.K. et al.
**摘要**：利用SPRR1A抗体进行共聚焦显微镜分析，揭示SPRR1A通过与桥粒蛋白结合参与皮肤机械稳定性调控，基因敲除导致小鼠表皮脆弱。
注：以上文献为示例性整理，实际引用时建议通过PubMed或Web of Science核对最新研究。部分早期研究可能涉及抗体HPA编号(如Sigma-Aldrich HPA047123)。
SPRR1A (Small Proline-Rich Protein 1A) is a member of the SPRR family, which comprises cysteine-rich proteins involved in epithelial differentiation and barrier function. Primarily expressed in keratinocytes, SPRR1A plays a critical role in forming the cornified cell envelope—a specialized structure essential for skin integrity and protection against environmental stressors. Its expression is tightly regulated during terminal keratinocyte differentiation and is often upregulated in response to inflammatory signals, oxidative stress, or tissue injury.
SPRR1A antibodies are valuable tools for studying epidermal biology, skin diseases, and squamous cell carcinomas. These antibodies enable the detection and localization of SPRR1A in tissues (e.g., via immunohistochemistry) or cell lysates (e.g., via Western blot), aiding research on its role in epithelial barrier dysfunction, wound healing, and pathological conditions like psoriasis or atopic dermatitis. Additionally, SPRR1A has been implicated in cancer research, as aberrant expression is observed in certain malignancies, potentially influencing tumor cell survival and drug resistance. Antibodies against SPRR1A are also utilized to explore its interactions with other cornified envelope proteins, such as involucrin or loricrin, and its cross-linking by transglutaminases during envelope assembly. Validation of SPRR1A antibodies typically includes testing specificity using knockout controls or recombinant proteins, ensuring accurate interpretation in experimental models of epithelial homeostasis and disease.
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