| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein YIPF5, Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 5, Smooth muscle cell-associated protein 5, SMAP-5, YIP1 family member 5, YPT-interacting protein 1 A, YIPF5, FINGER5, YIP1A |
| Entrez GeneID | 81555 |
| WB Predicted band size | 28.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This YIPF5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-49 amino acids from the N-terminal region of human YIPF5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于YIPF5 (N-term)抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: "YIPF5 regulates Golgi maturation and exocytosis by activating small GTPases"
**作者**: Zhang et al.
**摘要**: 该研究利用YIPF5 N-term抗体进行免疫荧光和Western blot实验，证明YIPF5通过激活ARF和Rab GTPases调控高尔基体成熟及分泌囊泡运输，影响细胞外泌蛋白的释放。
2. **文献名称**: "A novel role of YIPF5 in ER-Golgi protein trafficking and insulin secretion"
**作者**: Watanabe et al.
**摘要**: 通过YIPF5 N-term抗体定位，发现YIPF5在内质网-高尔基体蛋白运输中起关键作用，并参与胰岛β细胞的胰岛素分泌调控，为糖尿病机制研究提供新方向。
3. **文献名称**: "YIPF5 mutations cause a congenital disorder of glycosylation by disrupting ER-Golgi transport"
**作者**: Chen et al.
**摘要**: 研究使用YIPF5 N-term抗体进行患者细胞分析，揭示YIPF5基因突变导致糖基化异常疾病的分子机制，证实其在内质网-高尔基体运输中的必要性。
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**备注**：若需具体文献来源或补充更多条目，建议通过PubMed或Google Scholar以关键词“YIPF5 antibody”或“YIPF5 N-terminal”进一步检索近年研究。
**Background of YIPF5 (N-term) Antibody**
The YIPF5 (Yip1 domain family member 5) protein, also known as FinGER5 or NY-SAR-35. is a conserved transmembrane protein belonging to the Yip1 family, which plays a role in intracellular vesicle trafficking and membrane dynamics. YIPF5 is primarily localized to the Golgi apparatus and endoplasmic reticulum (ER), where it facilitates protein sorting, vesicle formation, and transport between these compartments. It interacts with other trafficking regulators, such as Rab GTPases, to maintain Golgi structure and mediate secretory pathways. Dysregulation of YIPF5 has been implicated in diseases like diabetes, neurodegenerative disorders, and cancer.
The YIPF5 (N-term) antibody is a specific immunological tool designed to target the N-terminal region of the human YIPF5 protein. This region often contains unique epitopes critical for antibody specificity, enabling selective detection of YIPF5 in various experimental applications. The antibody is typically produced in hosts like rabbits or mice using synthetic peptides or recombinant protein fragments corresponding to the N-terminal sequence.
Validated for techniques such as Western blotting, immunofluorescence, and immunohistochemistry, the YIPF5 (N-term) antibody aids in studying the protein’s expression, localization, and function in cellular and tissue contexts. Its use has advanced research on YIPF5’s role in Golgi-ER communication, secretion pathways, and disease mechanisms, making it a valuable reagent for cell biology and biomedical studies.
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