首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal RBP2 Antibody

  • 中文名: RBP2抗体
  • 别    名: Retinol-binding protein 2, Cellular retinol-binding protein II, CRBP-II, RBP2, CRBP2
货号: IPDX30514
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesRetinol-binding protein 2, Cellular retinol-binding protein II, CRBP-II, RBP2, CRBP2
Entrez GeneID5948
WB Predicted band size15.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis RBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-84 amino acids from the Central region of human RBP2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于RBP2抗体的3篇参考文献示例(注:以下内容为假设性示例,具体文献需根据实际数据库检索):

1. **文献名称**:*RBP2 Expression in Colorectal Cancer: A Novel Prognostic Marker*

**作者**:Zhang L, Wang Y, Chen H.

**摘要**:本研究通过免疫组化分析RBP2蛋白在结直肠癌组织中的表达,发现其高表达与患者生存率降低显著相关,提示RBP2可能作为潜在的预后标志物。

2. **文献名称**:*Development of a Monoclonal Antibody Against RBP2 for Functional Studies*

**作者**:Kim S, Tanaka M, Park J.

**摘要**:作者开发了一种高特异性的抗RBP2单克隆抗体,并通过Western blot和免疫荧光验证其有效性,应用于研究RBP2在细胞分化中的调控机制。

3. **文献名称**:*RBP2 Knockdown Impairs Retinoid Signaling in Epithelial Cells*

**作者**:Gupta R, Williams T, Liu X.

**摘要**:利用RBP2抗体检测基因敲除细胞模型,发现RBP2缺失会干扰视黄醇信号通路,影响上皮细胞的代谢与增殖功能。

(如需真实文献,建议通过PubMed或Google Scholar以“RBP2 antibody”或“RBP2 protein function”为关键词检索。)

背景信息

The retinoblastoma-binding protein 2 (RBP2), also known as JARID1A or KDM5A, is a member of the JARID1 family of histone demethylases. It specifically demethylates tri- and dimethylated lysine 4 on histone H3 (H3K4me3/me2), playing a critical role in epigenetic regulation by modulating chromatin structure and gene expression. Initially identified through its interaction with the retinoblastoma protein (pRB), RBP2 is implicated in cell cycle control, differentiation, and oncogenesis. Studies highlight its dual role in cancer: it can act as a tumor suppressor by repressing oncogenic pathways or as an oncogene by promoting proliferation and metastasis, depending on cellular context. Dysregulation of RBP2 has been linked to malignancies such as breast cancer, leukemia, and gastric cancer. RBP2 antibodies are essential tools for investigating its expression, localization, and function in biological systems. They are widely used in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to study its involvement in epigenetic mechanisms, developmental biology, and disease progression. These antibodies also aid in exploring potential therapeutic targets, as RBP2's enzymatic activity makes it a candidate for small-molecule inhibitors in cancer treatment.

客户数据及评论

折叠内容

大包装询价

×