| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Methionine adenosyltransferase 2 subunit beta, Methionine adenosyltransferase II beta, MAT II beta, Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase, MAT2B, TGR |
| Entrez GeneID | 27430 |
| WB Predicted band size | 37.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MAT2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-107 amino acids from the N-terminal region of human MAT2B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MAT2B (N-term)抗体的3篇参考文献示例(注：文献为虚构示例，仅作格式参考)：
1. **文献名称**：*Characterization of MAT2B N-terminal antibody in hepatocellular carcinoma models*
**作者**：Li, X. et al.
**摘要**：该研究开发并验证了一种针对MAT2B蛋白N端的特异性抗体，通过Western blot和免疫组化证实其在肝癌细胞系及组织中高表达，并揭示其与甲硫氨酸代谢异常的相关性。
2. **文献名称**：*MAT2B regulates AMPK signaling via N-terminal interactions: evidence from antibody-based inhibition assays*
**作者**：Garcia, R. et al.
**摘要**：利用MAT2B (N-term)抗体阻断N端结构域功能，研究发现MAT2B通过结合AMPK复合物调控能量代谢，为癌症治疗提供新靶点。
3. **文献名称**：*Development of a polyclonal antibody targeting the N-terminal domain of MAT2B and its application in colorectal cancer*
**作者**：Wang, Y. et al.
**摘要**：文章报道了一种靶向MAT2B N端的多克隆抗体的制备与验证，并应用于结直肠癌组织分析，发现MAT2B表达与患者预后显著相关。
(注：实际文献需通过PubMed/Google Scholar等平台以“MAT2B antibody”“N-terminal epitope”等关键词检索。)
The MAT2B (N-term) antibody targets the N-terminal region of methionine adenosyltransferase 2β (MAT2B), a regulatory subunit of the MATII enzyme complex. MATII catalyzes the synthesis of S-adenosylmethionine (SAMe), the primary methyl donor for cellular methylation reactions, including DNA, protein, and lipid modifications. MAT2B modulates MATII activity by binding to the catalytic subunit MAT2A, influencing SAMe levels and cellular methylation capacity. Dysregulation of MAT2B is implicated in metabolic disorders, liver diseases, and cancers, as altered SAMe levels affect epigenetic regulation and cellular proliferation.
The MAT2B (N-term) antibody is commonly used in research to study MAT2B expression, localization, and function. It is validated in applications such as Western blotting, immunohistochemistry, and immunofluorescence to detect endogenous MAT2B protein in human, mouse, or rat tissues and cell lines. By focusing on the N-terminal epitope, this antibody helps distinguish MAT2B from other MAT isoforms and assess post-translational modifications or interactions within the MATII complex. Its specificity makes it a valuable tool for exploring MAT2B's role in SAMe metabolism, cancer biology (e.g., hepatocellular carcinoma), and therapeutic targeting, particularly in contexts where MAT2B overexpression correlates with disease progression or drug resistance. Proper controls, such as knockout validation, are recommended to confirm signal specificity.
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