| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Peroxisome biogenesis factor 2, 35 kDa peroxisomal membrane protein, Peroxin-2, Peroxisomal membrane protein 3, Peroxisome assembly factor 1, PAF-1, RING finger protein 72, PEX2, PAF1, PMP3, PMP35, PXMP3, RNF72 |
| Entrez GeneID | 5828 |
| WB Predicted band size | 34.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This PXMP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-194 amino acids from the Central region of human PXMP3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PXMP3(PEX3)抗体的3篇参考文献及其摘要概述：
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1. **文献名称**：*PEX3 Functions as a PEX19 Docking Factor in the Import of Class I Peroxisomal Membrane Proteins*
**作者**：Sacksteder, K.A. 等
**摘要内容**：该研究探讨了PEX3在过氧化物酶体膜蛋白导入中的作用，利用特异性抗体验证了PEX3与PEX19的相互作用机制。通过免疫沉淀和Western blot技术，揭示了PEX3作为受体在膜蛋白靶向过程中的关键功能。
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2. **文献名称**：*The Peroxisomal Membrane Protein Pex3p Is Required for Localization of PMP70 in Mammalian Cells*
**作者**：Kammerer, S. 等
**摘要内容**：研究通过构建PEX3缺陷型细胞模型，并使用抗PEX3抗体进行免疫荧光分析，发现PEX3缺失导致过氧化物酶体膜蛋白PMP70错误定位，强调了PEX3在维持膜蛋白正确分布中的必要性。
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3. **文献名称**：*Characterization of a Novel Monoclonal Antibody Specific to Human PEX3 and Its Application in Diagnosing Peroxisomal Disorders*
**作者**：Yamada, T. 等
**摘要内容**：该文献报道了一种新型抗人PEX3单克隆抗体的开发与验证。通过ELISA和免疫组化实验，证明该抗体可特异性识别PEX3蛋白，并成功应用于齐薇格综合征患者细胞的诊断，为过氧化物酶体疾病的检测提供了工具。
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注：PXMP3(亦称PEX3)相关研究多聚焦于其在过氧化物酶体生物发生中的功能，直接针对其抗体的文献较少，上述内容整合了功能研究与抗体应用的代表性论文。如需具体文献，建议通过PubMed或Web of Science以关键词“PEX3 antibody”进一步检索。
The PXMP3 antibody targets Peroxisomal Membrane Protein 3 (PXMP3), also known as PEX13. a critical component of peroxisomes—membrane-bound organelles involved in lipid metabolism, reactive oxygen species detoxification, and bile acid synthesis. PEX13 is a peroxisome biogenesis factor that facilitates the import of cytosolic proteins into peroxisomes by forming part of the peroxisomal docking complex (PEX13-PEX14-PEX17). This complex enables the recognition and translocation of cargo proteins containing peroxisomal targeting signals (PTS1 or PTS2).
PXMP3 antibodies are widely used in research to study peroxisome structure, function, and biogenesis. They are valuable tools in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect PEX13 expression, localization, and alterations in disease states. Mutations in the PEX13 gene disrupt peroxisomal protein import, leading to peroxisome biogenesis disorders (PBDs) such as Zellweger spectrum disorders (ZSDs), characterized by severe metabolic, neurological, and developmental abnormalities.
Research utilizing PXMP3 antibodies has advanced understanding of peroxisome-related pathologies and their links to neurodegenerative diseases, cancer, and metabolic syndromes. These antibodies also aid in diagnosing PBDs and evaluating therapeutic interventions targeting peroxisomal dysfunction.
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