| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Myelin-associated oligodendrocyte basic protein, MOBP |
| Entrez GeneID | 4336 |
| WB Predicted band size | 21.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This MOBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MOBP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于MOBP(N-term)抗体的参考文献摘要(文献为示例性质，非真实存在)：
1. **标题**：Autoantibodies against myelin oligodendrocyte basic protein N-terminus in multiple sclerosis
**作者**：Smith J, et al.
**摘要**：该研究鉴定出多发性硬化患者血清中存在靶向MOBP蛋白N端(氨基酸1-80)的自身抗体，并通过ELISA和免疫印迹验证其特异性，提示其在疾病诊断中的潜在价值。
2. **标题**：Characterization of a novel monoclonal antibody targeting MOBP residues 15-30
**作者**：Tanaka K, et al.
**摘要**：研究者开发了一种针对MOBP N端15-30区域的小鼠单克隆抗体，证实其在冰冻切片中可特异性标记少突胶质细胞，为髓鞘相关研究提供新工具。
3. **标题**：Epitope mapping of MOBP-specific antibodies in neurodegenerative diseases
**作者**：Chen L, et al.
**摘要**：通过肽阵列技术分析发现，阿尔茨海默症患者脑脊液中部分抗体靶向MOBP的N端表位(aa 1-50)，提示该区域可能与神经炎症中的异常免疫应答相关。
注：以上文献信息为基于领域知识的模拟示例，实际文献需通过PubMed/Google Scholar检索关键词"MOBP antibody N-terminal"或"MOBP epitope mapping"获取。
The MOBP (Myelin-associated Oligodendrocyte Basic Protein) antibody targeting the N-terminal region (N-term) is a critical tool for studying myelination and demyelinating disorders. MOBP is a major component of myelin in the central nervous system (CNS), predominantly expressed in oligodendrocytes. It plays a structural role in maintaining myelin sheath stability and compactness through interactions with other myelin proteins like PLP and MBP. The N-terminal region of MOBP contains unique, highly basic amino acid residues that contribute to its function in myelin membrane adhesion and organization.
MOBP (N-term) antibodies are designed to specifically recognize epitopes within this N-terminal domain, enabling researchers to investigate MOBP expression, localization, and post-translational modifications in normal and diseased tissues. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study conditions like multiple sclerosis (MS), leukodystrophies, and traumatic brain injury, where myelin integrity is compromised. Additionally, they aid in distinguishing MOBP isoforms arising from alternative splicing, which may have distinct roles in myelination. The development of MOBP (N-term) antibodies has advanced our understanding of oligodendrocyte biology and CNS pathologies, offering potential diagnostic and therapeutic insights for demyelinating diseases.
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