关键信息
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基因名
Pka-C1
- 应用
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别名
Short name: PKA C
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种属
Drosophila melanogaster
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P12370
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表达区间
2-353aa
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分子量
56.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Pka-C1, a catalytic subunit of protein kinase A (PKA), plays a crucial role in cellular signaling pathways, influencing various physiological processes such as metabolism, gene expression, and cell growth. Understanding the structure and function of Pka-C1 is essential for elucidating its involvement in diseases, including cancer and metabolic disorders. Given its regulatory role in phosphorylating target proteins in response to cyclic AMP (cAMP) levels, researchers have focused on characterizing Pka-C1 through recombinant protein technologies. These studies often involve the expression of Pka-C1 in various host systems, such as bacteria, yeast, or mammalian cells, followed by purification and functional assays to assess its activity and interactions with other signaling molecules. Furthermore, insights into the mechanisms of Pka-C1 regulation and its downstream effects can pave the way for developing targeted therapeutics aimed at modulating PKA activity in pathological conditions. The ongoing research aims not only to deepen our understanding of Pka-C1’s role in cellular signaling but also to identify potential pharmacological targets to combat diseases linked to its dysregulation.
