| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein DLX-2, DLX2 |
| Entrez GeneID | 1746 |
| WB Predicted band size | 34.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This DLX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-222 amino acids from the Central region of human DLX2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DLX2抗体的3篇参考文献示例(内容为虚构，仅作格式参考)：
1. **文献名称**: "DLX2 regulates cranial neural crest development through β-catenin signaling"
**作者**: Smith A, et al.
**摘要**: 研究利用DLX2抗体在小鼠胚胎中通过免疫组化分析，揭示DLX2在颅神经嵴细胞分化和迁移中的作用，并发现其与Wnt/β-catenin通路的相互作用。
2. **文献名称**: "Expression of DLX2 in human glioblastoma and its role in tumor invasion"
**作者**: Chen L, et al.
**摘要**: 通过Western blot和免疫荧光实验(使用特异性DLX2抗体)，发现DLX2在胶质母细胞瘤中高表达，且通过调控MMP-9促进肿瘤细胞侵袭。
3. **文献名称**: "DLX2 as a marker for intestinal stem cell identity"
**作者**: Tanaka K, et al.
**摘要**: 研究利用DLX2抗体在小肠类器官模型中验证其作为肠道干细胞标志物的功能，证明DLX2通过调控Notch信号维持干细胞自我更新。
4. **文献名称**: "DLX2 antibody validation for single-cell RNA sequencing data"
**作者**: Müller S, et al.
**摘要**: 针对商业DLX2抗体的特异性进行验证(包括敲除实验和质谱分析)，为神经发育单细胞研究中DLX2蛋白表达的可靠性提供实验支持。
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(注：以上文献为示例，实际文献需通过PubMed等数据库检索确认。)
The DLX2 antibody is a key tool for studying the Distal-less homeobox 2 (DLX2) protein, a member of the DLX family of homeodomain transcription factors. DLX2 plays critical roles in embryonic development, particularly in neurogenesis, craniofacial patterning, and differentiation of GABAergic interneurons. It regulates gene expression by binding to specific DNA sequences, influencing cell fate determination and migration during neural crest and forebrain development. DLX2 is also implicated in skeletal morphogenesis, including craniofacial bone and jaw formation.
Antibodies targeting DLX2 are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to visualize its expression and localization in tissues, such as the developing brain, neural tube, and sensory organs. Researchers utilize these antibodies to investigate DLX2's involvement in neurodevelopmental disorders (e.g., autism, epilepsy) and cancers (e.g., glioblastoma), where its dysregulation may serve as a biomarker or therapeutic target.
Commercial DLX2 antibodies are often validated for specificity against epitopes in conserved regions (e.g., C-terminal domain), with clones like MAB9617 (Millipore) and ab181991 (Abcam) commonly cited. Proper validation using knockout controls is essential due to potential cross-reactivity with other DLX family members. Studies leveraging DLX2 antibodies continue to unravel its dual roles in developmental biology and disease pathogenesis.
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