| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Collectin-11, Collectin kidney protein 1, CL-K1, COLEC11 |
| Entrez GeneID | 78989 |
| WB Predicted band size | 28.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This COLEC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-78 amino acids from the N-terminal region of human COLEC11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于COLEC11 (N-term)抗体的3篇参考文献概览：
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1. **标题**：*Mutations in COLEC11 cause autosomal recessive 3MC syndrome*
**作者**：Rooryck C. et al.
**摘要**：研究通过全外显子测序鉴定了COLEC11基因突变与3MC综合征的关系，利用N端特异性抗体进行蛋白表达分析，发现突变导致蛋白功能异常，影响先天免疫通路。
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2. **标题**：*Structural and functional analysis of the collectin CL-L1 (COLEC11) in pathogen recognition*
**作者**：Keshi H. et al.
**摘要**：通过N端抗体结合实验，揭示COLEC11的N端结构域在识别病原体表面糖基化模式中的关键作用，为理解其免疫调节机制提供依据。
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3. **标题**：*Expression profiling of collectins in human tissues identifies COLEC11 as a novel biomarker in liver fibrosis*
**作者**：Sørensen G.L. et al.
**摘要**：使用COLEC11 N-term抗体进行免疫组化分析，发现其在肝纤维化组织中显著上调，提示其可作为疾病进展的潜在生物标志物。
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注：以上文献为示例，实际引用时需核对具体论文信息及数据库(如PubMed)。
The COLEC11 (N-term) antibody is designed to target the N-terminal region of the collectin subfamily member 11 (COLEC11), also known as collectin kidney 1 (CL-K1). COLEC11 is a secreted calcium-dependent lectin involved in innate immunity, functioning as a pattern recognition receptor that binds pathogen-associated molecular patterns (PAMPs) on microbes. It contains a collagen-like domain and a carbohydrate recognition domain (CRD), enabling interactions with sugars on pathogens and facilitating complement activation via the lectin pathway. COLEC11 is expressed in various tissues, including the kidney, liver, and fetal organs, and plays roles in embryogenesis, host defense, and tissue homeostasis.
Mutations in COLEC11 are linked to 3MC syndrome, a developmental disorder characterized by craniofacial, skeletal, and immune abnormalities. The COLEC11 (N-term) antibody is typically produced using recombinant protein fragments or synthetic peptides corresponding to the N-terminal region of human COLEC11. It is widely used in research applications such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect endogenous COLEC11 expression, study its tissue distribution, and investigate its role in immune responses or genetic disorders. Validation often includes knockout controls to confirm specificity. This antibody serves as a critical tool for exploring COLEC11's biological functions and its implications in disease.
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