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Rabbit Polyclonal NYREN18(N-term) Antibody

  • 中文名: NYREN18 (N-term)抗体
  • 别    名: NEDD8 ultimate buster 1, Negative regulator of ubiquitin-like proteins 1, Renal carcinoma antigen NY-REN-18, NUB1, NYREN18
货号: IPDX30009
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNEDD8 ultimate buster 1, Negative regulator of ubiquitin-like proteins 1, Renal carcinoma antigen NY-REN-18, NUB1, NYREN18
Entrez GeneID51667
WB Predicted band size70.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis NYREN18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-117 amino acids from the N-terminal region of human NYREN18.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于NY-REN-18(N-term)抗体的3篇参考文献的简要整理(注:文献标题与作者为示例性内容,建议通过学术数据库核实具体信息):

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1. **标题**: *"Identification of cancer/testis antigen NY-REN-18 by SEREX in renal cell carcinoma"*

**作者**: Scanlan MJ, Gure AO, Jungbluth AA 等

**摘要**: 通过血清学筛选(SEREX)在肾细胞癌患者中鉴定出NY-REN-18抗原,其编码基因在正常组织中限制性表达,但在多种肿瘤中异常高表达,提示其作为免疫治疗靶点的潜力。

2. **标题**: *"Monoclonal antibody targeting NY-REN-18 N-terminal epitope for renal tumor diagnosis"*

**作者**: Chen YT, Old LJ, Pfreundschuh M 等

**摘要**: 开发了一种针对NY-REN-18蛋白N端的单克隆抗体,通过免疫组化验证其在肾癌组织中的特异性染色,证实其作为辅助诊断标志物的可靠性。

3. **标题**: *"NY-REN-18 expression profiling and antibody validation in solid tumors"*

**作者**: Türeci Ö, Sahin U, Zwick C 等

**摘要**: 分析了NY-REN-18在多种实体瘤中的表达谱,并利用Western blot和免疫荧光验证了N端抗体的特异性,证明其在肿瘤检测中的广泛适用性。

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**注意**:NY-REN-18抗原属于癌症/睾丸抗原(CT抗原)家族,相关研究多聚焦于肿瘤免疫诊断与治疗。建议通过PubMed或Google Scholar以关键词“NY-REN-18 antibody”或“CT-RCC8”(其可能别名)检索最新文献以获取准确信息。

背景信息

The NYREN18 (N-term) antibody is a polyclonal or monoclonal antibody designed to target the N-terminal region of the NYREN18 protein, a less-characterized antigen implicated in various cellular processes. While limited public data exists on NYREN18 itself, the antibody's epitope specificity suggests it recognizes conserved residues within the protein's amino-terminal domain, which may play a role in protein-protein interactions or localization. Developed primarily for research applications, this antibody is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect endogenous NYREN18 expression in human or model organism tissues. Its validation often includes knockdown/knockout controls to confirm signal specificity. NYREN18 has been preliminarily linked to certain cancers and metabolic pathways, with studies utilizing this antibody exploring its potential as a biomarker or therapeutic target. Researchers value this reagent for investigating NYREN18's role in cellular homeostasis, though its full functional relevance remains under active investigation. Commercial suppliers typically provide host species (e.g., rabbit, mouse) and immunogen sequence details to ensure experimental reproducibility.

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