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Rabbit Polyclonal HDAC9(N-term) Antibody

  • 中文名: HDAC9 (N-term)抗体
  • 别    名: Histone deacetylase 9, HD9, Histone deacetylase 7B, HD7, HD7b, Histone deacetylase-related protein, MEF2-interacting transcription repressor MITR, HDAC9, HDAC7, HDAC7B, HDRP, KIAA0744, MITR
货号: IPDX30005
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 1/1000 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHistone deacetylase 9, HD9, Histone deacetylase 7B, HD7, HD7b, Histone deacetylase-related protein, MEF2-interacting transcription repressor MITR, HDAC9, HDAC7, HDAC7B, HDRP, KIAA0744, MITR
Entrez GeneID9734
WB Predicted band size111.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis HDAC9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human HDAC9.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于HDAC9 (N-term)抗体的3篇参考文献示例(注:内容为模拟概括,建议核实实际文献):

1. **文献名称**:*"HDAC9 regulates macrophage polarization in atherosclerosis via N-terminal deacetylase activity"*

**作者**:Zhang Y, et al. (2016)

**摘要**:研究利用针对HDAC9 N端的特异性抗体,通过Western blot和免疫荧光验证其在巨噬细胞中的表达,发现HDAC9通过其N端结构域调控炎症基因的表观遗传修饰,影响动脉粥样硬化进程。

2. **文献名称**:*"The role of HDAC9 in cardiac hypertrophy: Insights from N-terminal domain-specific antibody targeting"*

**作者**:Wang L, et al. (2018)

**摘要**:作者开发了一种HDAC9 N端抗体,用于检测心肌细胞中HDAC9的亚细胞定位。研究发现,HDAC9的N端乙酰化状态通过结合转录因子MEF2.参与病理性心肌肥厚的调控。

3. **文献名称**:*"HDAC9 N-terminal antibody reveals isoform-specific functions in neuronal differentiation"*

**作者**:Müller S, et al. (2020)

**摘要**:通过使用HDAC9 N端特异性抗体,该研究揭示了HDAC9不同剪接变体在神经干细胞分化中的差异表达,并证明其N端结构域对神经元突触可塑性的关键作用。

如需真实文献,建议在PubMed或Google Scholar中检索关键词:**"HDAC9 antibody N-terminal"** 或 **"HDAC9 N-term epitope"**,筛选涉及抗体开发、验证或功能研究的文章。

背景信息

The HDAC9 (N-term) antibody is a tool designed to detect histone deacetylase 9 (HDAC9), a member of the class IIa HDAC family involved in epigenetic regulation. HDAC9 modulates gene expression by removing acetyl groups from histones, leading to chromatin condensation and transcriptional repression. It plays roles in cellular processes such as differentiation, apoptosis, and immune response, with implications in cancer, cardiovascular diseases, and neurological disorders. The antibody specifically targets the N-terminal region of HDAC9. a domain critical for protein-protein interactions and regulatory functions, including binding to transcription factors or co-repressors. This region may also influence isoform-specific activity, as HDAC9 undergoes alternative splicing to generate variants with distinct biological properties. Researchers use the HDAC9 (N-term) antibody in techniques like Western blotting, immunofluorescence, or chromatin immunoprecipitation (ChIP) to study HDAC9 expression, localization, or its association with molecular pathways. Its specificity is often validated using HDAC9 knockout controls or siRNA-mediated knockdown to ensure minimal cross-reactivity with other HDAC family members. Studies leveraging this antibody have contributed to understanding HDAC9's role in T-cell regulation, smooth muscle cell plasticity, and its dual oncogenic/tumor-suppressive functions in different cancers. Proper validation and application-specific optimization are essential for reliable experimental outcomes.

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