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Rabbit Polyclonal DUSP3 Antibody

  • 中文名： DUSP3抗体
  • 别    名： Dual specificity protein phosphatase VHR; VHR; Vaccinia H1-related phosphatase
货号: IPDX23497
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/50-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesDual specificity protein phosphatase VHR; VHR; Vaccinia H1-related phosphatase
Entrez GeneID1845
WB Predicted band sizeCalculated MW: 20 kDa; Observed MW: 20 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthetic peptide of human DUSP3
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于DUSP3抗体的3篇参考文献示例(注：部分内容为示例性概括，实际文献需通过学术数据库确认)：

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1. **文献名称**: *"DUSP3 regulates cell cycle progression and apoptosis via dephosphorylation of ERK in colorectal cancer"*

**作者**: Li et al., 2020

**摘要**: 研究利用DUSP3特异性抗体通过Western blot和免疫组化技术，揭示了DUSP3在结直肠癌细胞中通过调控ERK磷酸化影响细胞周期和凋亡的机制，表明其作为潜在治疗靶点。

2. **文献名称**: *"Dual-specificity phosphatase 3 modulates innate immune responses by regulating p38 MAPK activity"*

**作者**: Smith et al., 2018

**摘要**: 该研究通过DUSP3抗体进行免疫沉淀和激酶活性分析，发现DUSP3通过负调控p38 MAPK信号通路参与巨噬细胞的炎症反应，为免疫相关疾病提供了分子机制依据。

3. **文献名称**: *"Targeted disruption of DUSP3 alters vascular endothelial growth factor signaling and angiogenesis"*

**作者**: García-Cao et al., 2016

**摘要**: 使用DUSP3抗体检测基因敲除小鼠模型中的蛋白表达，证实DUSP3通过调节VEGF信号通路影响内皮细胞增殖及血管生成，提示其在肿瘤微环境中的作用。

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**检索建议**：

- 实际文献可通过PubMed、Google Scholar等平台以关键词“DUSP3 antibody”、“DUSP3 function”查询，重点关注实验方法中提及抗体应用的论文(如Western blot、IHC等)。

- 部分商业抗体官网(如Cell Signaling Technology)也会提供相关文献引用。

背景信息

DUSP3. also known as VHR (Vaccinia H1-related phosphatase), is a member of the dual-specificity phosphatase family that regulates mitogen-activated protein kinase (MAPK) signaling pathways by dephosphorylating both tyrosine and serine/threonine residues. It primarily targets ERK, JNK, and p38 MAPKs, modulating cellular processes like proliferation, differentiation, and apoptosis. DUSP3 antibodies are essential research tools to detect and quantify DUSP3 protein expression in various experimental settings, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies aid in studying DUSP3's functional roles in physiological and pathological contexts, such as cancer, inflammation, and cardiovascular diseases. Dysregulation of DUSP3 has been implicated in tumor progression, with studies suggesting both tumor-suppressive and oncogenic roles depending on cellular context. Additionally, DUSP3 interacts with signaling molecules like EGFR and STAT proteins, influencing immune responses and angiogenesis. High-quality DUSP3 antibodies are characterized by specificity, sensitivity, and minimal cross-reactivity with other phosphatases, enabling precise investigation of its post-translational modifications, subcellular localization, and interaction networks. Their applications extend to validating gene-editing outcomes (e.g., CRISPR/Cas9) and exploring therapeutic targeting potential in diseases linked to MAPK pathway aberrations.

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