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Rabbit Polyclonal ENPP2 Antibody

  • 中文名: ENPP2抗体
  • 别    名: ENPP2; ATX; PDNP2; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; E-NPP 2; Autotaxin; Extracellular lysophospholipase D; LysoPLD
货号: IPDX23372
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesENPP2; ATX; PDNP2; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; E-NPP 2; Autotaxin; Extracellular lysophospholipase D; LysoPLD
Entrez GeneID5168
WB Predicted band sizeCalculated MW: 99 kDa; Observed MW: 99 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human ENPP2. AA range:401-450
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是3篇关于ENPP2抗体的参考文献示例(内容为模拟,非真实文献):

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1. **文献名称**: *"Monoclonal Antibody Targeting ENPP2 Suppresses Tumor Growth in Ovarian Cancer Models"*

**作者**: Smith J, et al. (2021)

**摘要**: 研究开发了一种靶向ENPP2的单克隆抗体,通过阻断其溶血磷脂酸(LPA)生成活性,显著抑制卵巢癌细胞侵袭和小鼠移植瘤的生长,表明其作为癌症治疗药物的潜力。

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2. **文献名称**: *"ENPP2 Neutralizing Antibody Attenuates Liver Fibrosis in Murine Models"*

**作者**: Tanaka K, et al. (2019)

**摘要**: 该研究验证了一种中和性ENPP2抗体在肝纤维化中的作用,发现抗体通过抑制LPA信号通路,减少胶原沉积和炎症反应,显著改善小鼠纤维化表型。

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3. **文献名称**: *"A Novel Anti-ENPP2 Antibody for Diagnostic Detection of Atherosclerotic Plaques"*

**作者**: Müller R, et al. (2020)

**摘要**: 研究报道了一种高特异性ENPP2抗体,可结合动脉粥样硬化斑块中的ENPP2蛋白,用于病理组织成像,为心血管疾病的诊断提供了新工具。

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4. **文献名称**: *"Autotaxin Inhibition via Antibody Therapy Reduces Obesity-Induced Insulin Resistance"*

**作者**: Lee S, et al. (2022)

**摘要**: 该团队开发的ENPP2(Autotaxin)抗体在小鼠模型中有效降低循环LPA水平,改善脂肪组织炎症和胰岛素敏感性,提示其在代谢疾病中的治疗价值。

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如需真实文献,建议通过PubMed或Google Scholar检索关键词(如“ENPP2 antibody”、“Autotaxin inhibitor”)。

背景信息

The ENPP2 antibody targets the enzyme Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2), also known as Autotaxin (ATX). ENPP2 is a secreted glycoprotein that catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to generate lysophosphatidic acid (LPA), a bioactive lipid mediator involved in diverse cellular processes, including proliferation, migration, and survival. ENPP2 plays critical roles in physiological processes such as embryonic development, angiogenesis, and neurogenesis, but its dysregulation is implicated in pathological conditions like cancer, fibrosis, inflammation, and metabolic disorders. Overexpression of ENPP2 has been observed in various cancers (e.g., breast, liver, glioblastoma), where it promotes tumor progression, metastasis, and angiogenesis by sustaining LPA-dependent signaling pathways.

ENPP2 antibodies are widely used in research to detect protein expression, localization, and activity in tissues or cell lines via techniques like Western blotting, immunohistochemistry, and ELISA. These antibodies aid in studying ENPP2’s role in disease mechanisms and validating its potential as a therapeutic target. Inhibiting ENPP2 activity, using small molecules or neutralizing antibodies, has shown promise in preclinical models for reducing LPA-driven pathologies. However, challenges remain in achieving selectivity and minimizing off-target effects. Research on ENPP2 antibodies continues to advance understanding of its complex interactions in health and disease, supporting the development of targeted therapies for cancer and other ENPP2-associated disorders.

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