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Rabbit Polyclonal CD1C Antibody

  • 中文名： CD1C抗体
  • 别    名： CD1C; T-cell surface glycoprotein CD1c; CD1c
货号: IPDX23367
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesCD1C; T-cell surface glycoprotein CD1c; CD1c
Entrez GeneID911
WB Predicted band sizeCalculated MW: 38 kDa; Observed MW: 38 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CD1C. AA range:211-260
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是关于CD1C抗体的3篇参考文献示例(信息基于公开研究内容概括，非真实文献，仅供参考)：

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1. **"CD1C-mediated lipid antigen presentation in human dendritic cells"**

*作者：Brigl M, et al. (2003)*

**摘要**：研究揭示了CD1C分子在人类树突状细胞中呈递脂质抗原的机制，证明其通过结合内源性脂质激活特定T细胞亚群，参与抗感染免疫应答。

2. **"CD1C as a biomarker for tumor-associated macrophages in solid tumors"**

*作者：Bai L, et al. (2018)*

**摘要**：通过免疫组化分析，发现CD1C抗体标记的肿瘤相关巨噬细胞(TAMs)与患者预后不良相关，提示CD1C可能成为癌症免疫治疗的潜在靶点。

3. **"Structural insights into CD1C-lipid complex recognition by antibodies"**

*作者：Zeng Z, et al. (2020)*

**摘要**：利用X射线晶体学解析CD1C-脂质复合物结构，阐明特定抗体识别CD1C抗原结合槽的分子机制，为开发靶向CD1C的免疫疗法提供理论基础。

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*注：以上为模拟文献，实际研究需通过学术数据库(如PubMed)查询真实论文。*

背景信息

CD1C antibodies are tools used to detect and study the CD1c protein, a member of the CD1 family of antigen-presenting molecules. CD1 molecules are structurally related to MHC class I but specialize in presenting lipid antigens to T cells, bridging innate and adaptive immunity. CD1c (CD1B2) is primarily expressed on dendritic cells, B cells, and certain epithelial cells, where it facilitates the presentation of self- and microbial lipids to invariant Natural Killer T (iNKT) cells and other T-cell subsets. This interaction is critical for immune surveillance, particularly against pathogens like mycobacteria and in regulating autoimmune responses. CD1c antibodies are widely used in research to identify CD1c-expressing cells via flow cytometry, immunohistochemistry, or Western blotting, aiding in the characterization of antigen-presenting cell populations. They also help investigate CD1c's role in diseases, such as cancer immunology, where altered lipid metabolism may influence CD1c-mediated immune evasion. Additionally, CD1c-targeting therapies, including antibody-drug conjugates or immunomodulatory agents, are under exploration. The development of CD1c antibodies has advanced understanding of lipid antigen presentation mechanisms and their implications in infection, autoimmunity, and cancer immunotherapy.

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