| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ODS1 |
| WB Predicted band size | 65 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ME2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MACC1抗体的3篇代表性文献(均为虚构示例，供参考格式)：
1. **文献名称**：*Development of a novel monoclonal antibody targeting MACC1 for colorectal cancer diagnosis*
**作者**：Stein, U., et al.
**摘要**：研究团队开发了一种靶向MACC1蛋白的单克隆抗体，通过免疫组化验证其在结直肠癌组织中的高表达，证实该抗体可用于患者预后评估和转移风险分层。
2. **文献名称**：*MACC1 antibody-based inhibition of metastatic progression in pancreatic cancer models*
**作者**：Giersch, M., et al.
**摘要**：利用抗MACC1抗体阻断其与c-Met信号通路的相互作用，在胰腺癌小鼠模型中显著抑制肿瘤转移，为靶向治疗提供了实验依据。
3. **文献名称**：*A sensitive ELISA assay using MACC1 antibody for early detection of hepatocellular carcinoma*
**作者**：Chen, L., et al.
**摘要**：基于MACC1抗体的新型ELISA检测方法在肝癌患者血清中显示出高灵敏度和特异性，有望成为早期诊断的生物标志物检测工具。
(注：以上文献信息为示例，实际引用需查询真实数据库如PubMed。)
The MACC1 (Metastasis-Associated in Colon Cancer 1) antibody is a crucial tool for studying the role of the MACC1 protein, a key regulator of cancer progression and metastasis. Discovered in 2009. MACC1 is a transcriptional activator of the hepatocyte growth factor (HGF)/MET signaling pathway, which drives cell proliferation, invasion, and metastatic spread. Overexpression of MACC1 is strongly linked to aggressive tumor behavior, poor prognosis, and metastasis in colorectal cancer and other malignancies, including gastric, lung, and liver cancers.
MACC1 antibodies are designed to detect and quantify MACC1 protein expression in research and diagnostic settings. These antibodies (often monoclonal or polyclonal) are used in techniques like Western blotting, immunohistochemistry (IHC), and ELISA to analyze tissue samples, cell lines, or biological fluids. Their applications include investigating MACC1's molecular mechanisms, validating its role as a prognostic biomarker, and exploring its potential as a therapeutic target.
Clinically, MACC1 antibodies aid in stratifying patients based on metastasis risk and monitoring treatment response. Preclinical studies also leverage these antibodies to evaluate novel anti-MACC1 strategies, such as gene silencing or inhibitory compounds. Despite their utility, challenges remain in standardizing detection protocols and ensuring specificity across cancer types. Ongoing research aims to refine antibody performance and expand their use in personalized oncology.
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