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Rabbit Polyclonal NUP88 Antibody

  • 中文名： NUP88抗体
  • 别    名： NUP88; Nuclear pore complex protein Nup88; 88 kDa nucleoporin; Nucleoporin Nup88
货号: IPDX23355
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesNUP88; Nuclear pore complex protein Nup88; 88 kDa nucleoporin; Nucleoporin Nup88
Entrez GeneID4927
WB Predicted band sizeCalculated MW: 84 kDa; Observed MW: 84 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenSynthesized peptide derived from Nup88 . at AA range: 330-410
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是关于NUP88抗体的模拟参考文献示例(注：文献为虚构，仅供参考格式)：

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1. **文献名称**: "NUP88 Overexpression in Ovarian Carcinoma: Correlation with Clinicopathological Features"

**作者**: Müller, A., et al.

**摘要**: 通过免疫组化(使用抗NUP88抗体)分析卵巢癌组织样本，研究发现NUP88在高级别肿瘤中显著过表达，并与淋巴结转移和不良预后相关，提示其作为潜在治疗靶点的可能性。

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2. **文献名称**: "NUP88 Antibody Validation for Detecting Nuclear Envelope Abnormalities in Leukemia"

**作者**: Tanaka, K., et al.

**摘要**: 本研究评估了商业抗NUP88抗体的特异性，发现其在检测白血病细胞中NUP88与NUP214的异常融合蛋白时具有高敏感性，为白血病分子诊断提供了可靠工具。

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3. **文献名称**: "Role of NUP88 in Hepatitis B Virus Capsid Transport: Insights from Antibody-Mediated Inhibition"

**作者**: Chen, L., et al.

**摘要**: 利用抗NUP88抗体阻断核孔功能，发现HBV衣壳蛋白的核质运输依赖NUP88.揭示了病毒利用宿主核孔复合体完成感染的新机制。

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4. **文献名称**: "Development of Monoclonal Antibodies Targeting NUP88 for Cancer Immunotherapy"

**作者**: Rossi, G., et al.

**摘要**: 研究团队开发了靶向NUP88的单克隆抗体，并在体外实验中证实其能特异性结合肿瘤细胞核膜，诱导凋亡，为基于核孔蛋白的癌症免疫治疗提供了新思路。

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如需真实文献，建议通过PubMed或Google Scholar搜索“NUP88 antibody”“NUP88 cancer”等关键词获取最新研究。

背景信息

NUP88 (nucleoporin 88 kDa) is a component of the nuclear pore complex (NPC), a critical structure mediating nucleocytoplasmic transport. It interacts with other nucleoporins, such as NUP98 and NUP214. to maintain NPC architecture and regulate molecular trafficking. NUP88 is overexpressed in various cancers, including leukemia, ovarian carcinoma, and lung cancer, and is implicated in oncogenic processes. Its dysregulation is associated with altered cell cycle control, apoptosis resistance, and enhanced cell proliferation. Antibodies targeting NUP88 are essential tools for studying its expression, localization, and interactions in both physiological and pathological contexts. In research, NUP88 antibodies are widely used in techniques like immunohistochemistry, immunofluorescence, and Western blotting to investigate its role in cancer progression and NPC dysfunction. Clinically, elevated NUP88 levels may serve as a diagnostic or prognostic marker, particularly in malignancies linked to chromosomal rearrangements involving NUP98. Studies also explore its potential as a therapeutic target, given its involvement in oncogenic pathways. The specificity and reliability of NUP88 antibodies are crucial for validating experimental findings and advancing translational research in oncology and cell biology.

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