| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | B3GALT1; Beta-1; 3-galactosyltransferase 1; Beta-1; 3-GalTase 1; Beta3Gal-T1; Beta3GalT1; UDP-galactose:beta-N-acetyl-glucosamine-beta-1; 3-galactosyltransferase 1 |
| Entrez GeneID | 8708 |
| WB Predicted band size | Calculated MW: 38 kDa; Observed MW: 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | The antiserum was produced against synthesized peptide derived from human B3GALT1. AA range:61-110 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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由于我无法访问实时数据库或具体文献内容，以下为示例格式的模拟参考文献(非真实存在，仅供示例参考)：
1. **文献名称**: "Characterization of β3Gal-T1 in Glycan Synthesis"
**作者**: Smith A, et al.
**摘要**: 研究β3Gal-T1在O-糖基化中的作用，发现其调控特定肿瘤细胞表面抗原表达，抗体阻断可抑制癌细胞迁移。
2. **文献名称**: "B3GALT1 Antibody in Autoimmunity"
**作者**: Lee B, et al.
**摘要**: 通过小鼠模型证明抗β3Gal-T1抗体可干预IgA肾病进程，提示其作为潜在治疗靶点。
3. **文献名称**: "Structural Insights into β3Gal-T1"
**作者**: Chen C, et al.
**摘要**: 解析β3Gal-T1晶体结构，阐明抗体结合表位，为开发特异性诊断工具提供依据。
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**建议检索方法**：
1. 在 **PubMed/Google Scholar** 搜索关键词：`"B3GALT1 antibody"`、`"β3Gal-T1 function"`。
2. 按“引用量”或“时间”排序，优先选择近5年或高被引论文。
3. 关注期刊如《Glycobiology》《Journal of Biological Chemistry》。
如需进一步协助文献筛选或管理，可告知具体需求。
The β3GalT1 (β3-galactosyltransferase 1) antibody is a tool used to study the enzyme β3GalT1. a member of the glycosyltransferase family. This enzyme catalyzes the transfer of galactose residues to glycoproteins and glycolipids via β1-3 linkages, playing a critical role in synthesizing carbohydrate epitopes such as the Lewis antigens and core structures of O- and N-linked glycans. These glycoconjugates are essential for cell-cell interactions, immune responses, and cellular signaling. β3GalT1 is implicated in diverse biological processes, including embryogenesis, cancer progression, and pathogen recognition.
The β3GalT1 antibody is widely utilized in research to investigate the enzyme's expression, localization, and function in normal and diseased tissues. It has applications in techniques like Western blotting, immunohistochemistry, and flow cytometry, enabling detection of β3GalT1 in various biological samples. Studies using this antibody have revealed its involvement in tumor metastasis, where altered glycosylation patterns correlate with invasive potential. Additionally, β3GalT1 is linked to immune regulation, as its activity influences leukocyte trafficking and inflammation.
Developed in multiple host species (e.g., rabbit, mouse), the antibody’s specificity and validation are critical for reliable data. Its use extends to exploring therapeutic targets, particularly in cancers with dysregulated glycosylation. By elucidating β3GalT1's role in health and disease, this antibody contributes to advancing glycobiology and precision medicine research.
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