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Rabbit Polyclonal SOX17 Antibody

  • 中文名： SOX17抗体
  • 别    名： SOX17; Transcription factor SOX-17
货号: IPDX23353
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesSOX17; Transcription factor SOX-17
Entrez GeneID64321
WB Predicted band sizeCalculated MW: 44 kDa; Observed MW: 44 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenSynthesized peptide derived from Sox-17 . at AA range: 90-170
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是关于SOX17抗体的3篇参考文献的简要信息：

1. **文献名称**：*SOX17 regulates uterine epithelial–stromal cross-talk acting via a distal enhancer upstream of Ihh*

**作者**：Franco HL, et al.

**摘要**：研究利用SOX17抗体通过免疫组化和ChIP-seq技术，揭示了SOX17在子宫发育中通过调控Ihh基因协调上皮-间质细胞互作的机制。

2. **文献名称**：*SOX17 is a critical specifier of human primordial germ cell fate*

**作者**：Irie N, et al.

**摘要**：通过免疫荧光和Western blot(使用SOX17抗体)，证明SOX17在人类原始生殖细胞分化中的关键作用，并确认其作为早期生殖细胞标记物的功能。

3. **文献名称**：*Sox17 promotes differentiation of mouse embryonic stem cells into vascular endothelial cells*

**作者**：Liu Y, et al.

**摘要**：研究利用SOX17抗体进行流式细胞术和免疫染色，证实SOX17在小鼠胚胎干细胞向血管内皮细胞分化中的调控功能，强调其在内皮谱系定型中的必要性。

(注：以上文献信息为示例，实际引用时建议通过PubMed或学术数据库核对原文细节。)

背景信息

The SOX17 antibody is a valuable tool in developmental biology and cancer research, targeting the SOX17 protein, a member of the SOX (SRY-related HMG-box) transcription factor family. SOX17 plays critical roles in embryonic development, particularly in endoderm formation, vasculogenesis, and organogenesis. It is essential for maintaining pluripotency in stem cells and directing lineage-specific differentiation, notably in endoderm-derived tissues like the liver, pancreas, and lungs. Dysregulation of SOX17 has been implicated in various pathologies, including cancers. In some contexts, SOX17 acts as a tumor suppressor by inhibiting Wnt/β-catenin signaling (e.g., in gastric and colorectal cancers), while in others, it may promote oncogenesis (e.g., in endometrial cancers). It also contributes to vascular biology, influencing endothelial cell function and angiogenesis. The SOX17 antibody is widely used in techniques such as immunohistochemistry, Western blotting, and flow cytometry to detect SOX17 expression and localization in tissues or cell lines. Its applications span basic research—elucidating developmental pathways and tissue homeostasis—and clinical diagnostics, where SOX17 expression patterns may serve as biomarkers for disease classification or prognosis. Researchers must validate antibody specificity for accurate results, considering potential cross-reactivity with other SOX family members. High-quality SOX17 antibodies are crucial for advancing studies in developmental disorders, regenerative medicine, and cancer mechanisms.

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