| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ETGF; TFGA; TGF A; TGF-alpha; Tgfa; Wa1; Waved 1 |
| Entrez GeneID | 7039 |
| WB Predicted band size | Calculated MW: 17 kDa; Observed MW: 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human TGF alpha |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TGF-α抗体的3篇示例参考文献(注：以下内容为模拟生成，非真实文献)：
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1. **文献名称**: "Neutralizing TGF-α Antibody Inhibits Tumor Growth in Colorectal Cancer Models"
**作者**: Smith J., et al.
**摘要**: 研究通过体外和小鼠模型证明，中和性TGF-α抗体可阻断EGFR信号通路，显著抑制结直肠癌细胞的增殖和肿瘤生长，提示其作为潜在靶向疗法的可能性。
2. **文献名称**: "Development of a High-Specificity Monoclonal Antibody for TGF-α Detection in Human Serum"
**作者**: Lee H., et al.
**摘要**: 报道一种新型单克隆抗体的开发，该抗体能特异性识别人类血清中的TGF-α，灵敏度高且交叉反应性低，为癌症早期诊断和生物标志物检测提供工具。
3. **文献名称**: "TGF-α Antibody Enhances Chemotherapy Efficacy in Triple-Negative Breast Cancer"
**作者**: Garcia R., et al.
**摘要**: 研究发现，联合使用TGF-α抗体与标准化疗药物可显著增强三阴性乳腺癌的治疗效果，机制涉及抑制肿瘤微环境中的促生存信号通路。
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(注：如需真实文献，建议通过PubMed或Google Scholar检索关键词如"TGF-alpha antibody therapy"或"anti-TGF-alpha neutralizing antibody"获取。)
**Background of TGF Alpha Antibody**
Transforming Growth Factor-alpha (TGF-α) is a member of the epidermal growth factor (EGF) family, playing a critical role in cell proliferation, differentiation, and tissue repair. It binds to the epidermal growth factor receptor (EGFR), activating downstream signaling pathways like MAPK and PI3K-Akt, which regulate cellular growth and survival. TGF-α is implicated in physiological processes, including embryonic development and wound healing, but its dysregulation is associated with pathological conditions, particularly cancer. Overexpression of TGF-α has been observed in various tumors, promoting angiogenesis, metastasis, and resistance to therapy.
TGF-alpha antibodies are tools designed to detect, neutralize, or modulate TGF-α activity. These antibodies are widely used in research to study TGF-α’s role in cancer biology, inflammatory diseases, and tissue regeneration. In diagnostics, they aid in detecting TGF-α levels in biological samples, correlating with disease progression or therapeutic response. Therapeutically, TGF-alpha-blocking antibodies are explored to inhibit EGFR signaling in cancers, though challenges like specificity and off-target effects remain.
Recent advancements in monoclonal antibody technology have improved the affinity and specificity of TGF-alpha antibodies, enhancing their utility in both experimental and clinical settings. Their dual role as research reagents and potential therapeutics underscores their importance in understanding and targeting TGF-α-related pathways in disease.
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