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Rabbit Polyclonal IKKgamma Antibody

  • 中文名： IKK gamma抗体
  • 别    名： IKBKG; FIP3; NEMO; NF-kappa-B essential modulator; NEMO; FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF
货号: IPDX22933
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/50-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesIKBKG; FIP3; NEMO; NF-kappa-B essential modulator; NEMO; FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF
Entrez GeneID8517
WB Predicted band sizeCalculated MW: 48 kDa; Observed MW: 48 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human IKK gamma
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于IKK gamma(NEMO)抗体的3篇代表性文献的简要总结(注：文献信息为模拟示例，仅供参考)：

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1. **标题**：*"A monoclonal antibody specific for IKK gamma/NEMO in the NF-κB signaling pathway"*

**作者**：Chen ZJ, et al.

**摘要**：该研究开发了一种针对IKK gamma/NEMO的高特异性单克隆抗体，并通过免疫沉淀和Western blot验证其在人源细胞系中的有效性。抗体成功用于检测IKK复合物的组装，并揭示了NEMO在炎症反应中调控NF-κB活性的关键作用。

2. **标题**：*"IKK gamma deficiency in dendritic cells disrupts adaptive immunity: Insights from antibody-based profiling"*

**作者**：Li Q, et al.

**摘要**：研究者利用IKK gamma抗体通过免疫组化技术，分析树突状细胞中NEMO蛋白的亚细胞定位。结果发现，IKK gamma缺失导致NF-κB信号传导异常，进而影响T细胞活化，为免疫缺陷疾病的机制提供了新证据。

3. **标题**：*"Targeting IKK gamma in cancer: Antibody-mediated inhibition suppresses tumor growth in vivo"*

**作者**：Wang X, et al.

**摘要**：该研究通过构建靶向IKK gamma的功能阻断型抗体，证明其在乳腺癌小鼠模型中能够抑制NF-κB依赖的肿瘤增殖和转移，提示IKK gamma抗体在癌症治疗中的潜在应用价值。

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如需获取真实文献，建议在PubMed或Google Scholar中检索关键词：**IKK gamma antibody**、**NEMO antibody**、**IKBKG antibody**，并筛选近年发表的研究论文或抗体开发相关技术文献。

背景信息

The IKK gamma antibody targets the inhibitor of nuclear factor kappa-B kinase subunit gamma (IKKγ), also known as NF-kappa-B essential modulator (NEMO). As a regulatory component of the IKK complex, IKKγ plays a critical role in activating the NF-κB signaling pathway, which regulates immune responses, inflammation, and cell survival. Unlike the catalytic subunits IKKα and IKKβ, IKKγ lacks kinase activity but is essential for complex assembly and signal transduction. It contains a zinc finger domain and ubiquitin-binding regions, enabling interactions with upstream signaling molecules like RIP1 and TRAF6 during TNF or IL-1 receptor activation. Mutations in the IKKγ gene are linked to human diseases, including incontinentia pigmenti (IP) and immunodeficiency disorders such as X-linked ectodermal dysplasia and immunodeficiency (EDA-ID). Antibodies against IKKγ are widely used in research to study NF-κB activation mechanisms, protein-protein interactions, and subcellular localization via techniques like Western blotting, immunoprecipitation, and immunofluorescence. They also aid in diagnosing genetic disorders and exploring therapeutic strategies for cancers and chronic inflammatory diseases. Due to its central role in immune regulation, IKKγ remains a key focus in understanding pathological processes and developing targeted therapies.

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