| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HNC, CLG1, MMP-8, PMNL-CL |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MMP8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BMP11(GDF11)抗体的3篇代表性文献的模拟示例(基于领域知识，非真实文献)：
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1. **标题**：*Monoclonal Antibody Targeting BMP11 Reveals Its Role in Skeletal Muscle Regeneration*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种特异性靶向BMP11的单克隆抗体，证实其通过抑制BMP11/Smad信号通路促进小鼠骨骼肌损伤后的再生，为肌肉退行性疾病治疗提供潜在工具。
2. **标题**：*A Neutralizing Anti-BMP11 Antibody Improves Glucose Metabolism in Ageing Mice*
**作者**：Chen L, et al.
**摘要**：通过中和性抗体阻断BMP11活性，发现老年小鼠的胰岛素敏感性和葡萄糖代谢显著改善，提示BMP11在代谢衰老中的调控作用及抗体干预的潜在价值。
3. **标题**：*Development of a High-Affinity BMP11 Antibody for Immunohistochemical Applications*
**作者**：Wang Y, et al.
**摘要**：报道一种高亲和力多克隆抗体的制备，成功用于BMP11在小鼠心脏和胰腺组织的定位分析，为研究其在器官发育中的时空表达提供可靠工具。
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注：以上文献为示例性质，实际引用时建议通过PubMed或Web of Science检索最新研究。若需具体文献，可补充说明研究方向(如疾病应用、抗体类型等)。
The BMP11 antibody is a crucial tool for studying bone morphogenetic protein 11 (BMP11), also known as growth differentiation factor 11 (GDF11). BMP11. a member of the TGF-β superfamily, regulates diverse biological processes, including embryonic development, tissue homeostasis, and metabolic balance. It plays roles in skeletal patterning, neurogenesis, and organogenesis, and has been implicated in age-related conditions due to its debated effects on muscle regeneration and stem cell differentiation.
BMP11 antibodies are designed to detect and quantify endogenous BMP11 protein levels in experimental models. They are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to investigate BMP11 expression patterns, signaling pathways, and interactions with receptors (e.g., ALK4/5/7 and ActRIIB). Researchers employ these antibodies to explore BMP11's involvement in diseases such as muscular atrophy, osteoporosis, cancer, and metabolic disorders.
Commercial BMP11 antibodies vary in clonality (monoclonal/polyclonal), species reactivity (human, mouse, rat), and epitope specificity. Validation parameters, including knockout validation and cross-reactivity checks, are critical for ensuring reliability. Challenges include distinguishing BMP11 from homologous proteins (e.g., GDF8/myostatin) and interpreting its context-dependent roles in tissue repair or fibrosis. Ongoing research aims to clarify BMP11's therapeutic potential, making its antibodies essential for mechanistic studies and drug development.
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