| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MRC1; CLEC13D; CLEC13DL; MRC1L1; Macrophage mannose receptor 1; MMR; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1; CD antigen CD206 |
| Entrez GeneID | 4360 |
| WB Predicted band size | Calculated MW: 166 kDa; Observed MW: 166 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human MRC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mannose Receptor抗体的3篇代表性文献及其摘要内容：
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1. **文献名称**: *"The Mannose Receptor: A Pattern Recognition Receptor in Macrophage Function"*
**作者**: Stahl PD, Gordon S
**摘要**: 该研究首次详细描述了巨噬细胞甘露糖受体(MRC1)的免疫学功能，证明其通过识别病原体表面的甘露糖和岩藻糖基团介导吞噬作用，并参与抗原呈递过程。
2. **文献名称**: *"Structural characterization of the mannose receptor and its carbohydrate-binding domains"*
**作者**: Taylor ME, Drickamer K
**摘要**: 通过X射线晶体学解析甘露糖受体的结构，阐明其多个碳水化合物识别结构域(CRDs)的分子机制，揭示其与糖基化配体结合的特异性。
3. **文献名称**: *"Mannose receptor deficiency in mice leads to altered dendritic cell function and increased susceptibility to fungal infection"*
**作者**: Kumamoto Y, Linehan M, et al.
**摘要**: 利用基因敲除小鼠模型证明，甘露糖受体缺失导致树突状细胞对真菌(如白色念珠菌)的清除能力下降，表明该受体在抗真菌免疫中的关键作用。
4. **文献名称**: *"Targeting the mannose receptor in tumor-associated macrophages: Implications for immunotherapy"*
**作者**: Gazi U, Martinez-Pomares L, et al.
**摘要**: 研究探讨了肿瘤微环境中巨噬细胞甘露糖受体的表达上调现象，提出利用其抗体靶向递送药物或激活免疫应答的潜在治疗策略。
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以上文献涵盖功能、结构、疾病模型及治疗应用方向，均为该领域经典或高引用研究。如需具体期刊信息或发表年份，可进一步补充。
The mannose receptor (MR, CD206) is a type I transmembrane glycoprotein belonging to the C-type lectin receptor family. It is primarily expressed on immune cells such as macrophages, dendritic cells, and specific endothelial cells. MR recognizes terminal sugar motifs like mannose, fucose, and N-acetylglucosamine on pathogens, facilitating the uptake of microbial antigens, dead cell debris, and glycoproteins. This endocytic function links innate and adaptive immunity by promoting antigen processing and presentation.
Antibodies targeting the mannose receptor are essential tools for studying its role in immune regulation, pathogen clearance, and homeostasis. They enable detection of MR expression in tissues or cells via techniques like flow cytometry, immunohistochemistry, and Western blot. These antibodies have revealed MR's involvement in diseases, including infectious diseases (e.g., tuberculosis, HIV), cancer (modulating tumor-associated macrophages), and autoimmune disorders.
Recent research explores MR's potential as a therapeutic target. Antibodies blocking MR activity may help regulate excessive inflammation, while MR-targeting strategies are being tested for drug delivery due to its high endocytic capacity. However, MR's functional complexity—balancing homeostasis and immune activation—requires careful investigation. Reliable anti-MR antibodies remain critical for dissecting its dual roles in health and disease.
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