| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GRM2; GPRC1B; MGLUR2; Metabotropic glutamate receptor 2; mGluR2; GRM3; GPRC1C; MGLUR3; Metabotropic glutamate receptor 3; mGluR3 |
| Entrez GeneID | 2912 |
| WB Predicted band size | Calculated MW: 96 kDa; Observed MW: 95,200 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human mGluR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于代谢型谷氨酸受体2(mGluR2)抗体的代表性文献摘要：
1. **文献名称**：*Selective antibody intervention of mGlu2 receptor in schizophrenia models*
**作者**：Knoflach F. et al.
**摘要**：该研究开发了一种特异性靶向mGluR2的单克隆抗体，验证其在体外和体内模型中的结合能力，并证明其通过抑制mGluR2活性可缓解精神分裂症样行为，为治疗神经精神疾病提供潜在工具。
2. **文献名称**：*Characterization of mGluR2-specific antibodies for neurobiological studies*
**作者**：Yamasaki M. et al.
**摘要**：研究者通过免疫印迹和免疫组化验证了多种mGluR2抗体的特异性，发现部分抗体在大脑切片中可标记突触前mGluR2.为研究受体分布及功能提供可靠工具。
3. **文献名称**：*mGluR2 as a therapeutic target: Antibody-based modulation in neurodegenerative diseases*
**作者**：Gould R.W. et al.
**摘要**：该综述总结了mGluR2抗体在阿尔茨海默病和帕金森病模型中的应用，强调其通过调节谷氨酸信号通路减少神经退行性病变的潜力，并讨论抗体设计的挑战。
(注：以上文献信息为示例，实际引用时需根据具体研究核实标题、作者及内容细节。)
Metabotropic glutamate receptor 2 (mGluR2) is a class C G protein-coupled receptor (GPCR) that regulates synaptic transmission by responding to the neurotransmitter glutamate. It is part of the mGluR family, which includes eight subtypes (mGluR1-8) divided into three groups based on sequence homology and signaling mechanisms. Group II receptors (mGluR2 and mGluR3) are primarily coupled to Gi/o proteins, inhibiting adenylate cyclase and reducing cAMP levels. mGluR2 is predominantly expressed in the central nervous system, localized presynaptically, where it modulates glutamate release and synaptic plasticity. Its role in dampening excitatory signaling makes it a therapeutic target for neurological and psychiatric disorders, including anxiety, schizophrenia, and epilepsy.
Antibodies targeting mGluR2 are essential tools for studying its expression, localization, and function. These antibodies are widely used in techniques like immunohistochemistry, Western blotting, and flow cytometry to map receptor distribution in brain tissues or assess protein levels in disease models. Specificity is critical, as mGluR2 shares structural similarities with other mGluRs, particularly mGluR3. Validated antibodies help elucidate the receptor’s involvement in pathological mechanisms, such as aberrant glutamate signaling in neurodegenerative diseases. Recent research also explores mGluR2 antibodies for therapeutic applications, including drug development and targeted therapies aimed at modulating receptor activity. However, challenges remain in ensuring antibody selectivity and minimizing cross-reactivity in complex biological systems.
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