| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/50-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ITGA5; FNRA; Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD49e |
| Entrez GeneID | 3678 |
| WB Predicted band size | Calculated MW: 115 kDa; Observed MW: 150 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Integrin alpha 5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Integrin alpha 5抗体的3篇参考文献，简要总结如下：
1. **文献名称**：*Targeting Integrin α5β1 in Cancer: Preclinical and Clinical Advances*
**作者**：Chen et al. (2020)
**摘要**：探讨Integrin α5β1在肿瘤血管生成和转移中的作用，研究其抗体在抑制肿瘤生长和增强化疗效果中的潜力，总结了临床前模型和早期临床试验结果。
2. **文献名称**：*Integrin α5 Blockade Inhibits Fibrosis in a Murine Model of Pulmonary Fibrosis*
**作者**：Sulochana et al. (2018)
**摘要**：通过小鼠模型证明，抑制Integrin α5可减少TGF-β信号通路激活，降低细胞外基质沉积，为肺纤维化治疗提供新靶点。
3. **文献名称**：*Antibody-mediated Disruption of Integrin α5β1-Extracellular Matrix Interactions Suppresses Breast Cancer Progression*
**作者**：Bello et al. (2017)
**摘要**：研究发现Integrin α5抗体通过阻断肿瘤细胞与纤维连接蛋白的结合，抑制乳腺癌细胞迁移和侵袭，提示其作为辅助治疗的潜力。
如需具体文献链接或更多信息，可进一步检索PubMed或相关数据库。
Integrin alpha 5 (ITGA5) is a critical subunit of the α5β1 heterodimeric integrin receptor, a transmembrane protein involved in cell-matrix adhesion and bidirectional signaling. As part of the integrin family, ITGA5 binds specifically to fibronectin through its Arg-Gly-Asp (RGD) recognition motif, mediating cellular processes such as migration, proliferation, and survival. This receptor plays essential roles in embryonic development, angiogenesis, tissue repair, and pathological conditions including cancer metastasis and fibrosis.
Antibodies targeting integrin alpha 5 are widely used in research to study its expression, localization, and functional interactions. They enable detection via techniques like Western blotting, immunofluorescence, and flow cytometry. In cancer biology, these antibodies help assess ITGA5 overexpression linked to tumor invasiveness and poor prognosis. Therapeutic applications are also explored, as blocking α5β1-fibronectin interactions may inhibit tumor angiogenesis or fibrosis progression. However, clinical translation remains challenging due to integrin signaling complexity and off-target effects. Commercially available antibodies vary in specificity (monoclonal vs. polyclonal) and host species, requiring validation for experimental contexts. Recent studies further investigate ITGA5's role in mechanotransduction and stem cell niches, expanding its biomedical relevance.
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