| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/50-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PRDX2; NKEFB; TDPX1; Peroxiredoxin-2; Natural killer cell-enhancing factor B; NKEF-B; PRP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1 |
| Entrez GeneID | 7001 |
| WB Predicted band size | Calculated MW: 22 kDa; Observed MW: 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Peroxiredoxin 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4篇关于Peroxiredoxin 2(PRDX2)抗体的参考文献及其简要摘要：
1. **文献名称**: "Peroxiredoxin 2 as a biomarker for early diagnosis of hepatocellular carcinoma"
**作者**: Kim, J. et al.
**摘要**: 该研究利用PRDX2抗体检测肝细胞癌患者血清中的PRDX2表达水平，发现其可作为早期诊断的生物标志物，并与氧化应激相关通路异常激活有关。
2. **文献名称**: "Peroxiredoxin 2 deficiency exacerbates neurodegeneration in a mouse model of Alzheimer's disease"
**作者**: Basso, M. et al.
**摘要**: 通过PRDX2抗体在小鼠脑组织中的免疫组化分析，发现PRDX2缺失会加剧β-淀粉样蛋白沉积引起的氧化损伤，提示其在神经保护中的作用。
3. **文献名称**: "Crystal structure of human peroxiredoxin 2 reveals structural changes linked to antioxidant activity"
**作者**: Nelson, K.J. & Parsonage, D.
**摘要**: 使用PRDX2抗体辅助纯化蛋白并进行结构解析，阐明了PRDX2的抗氧化功能与其二聚体构象的动态变化密切相关。
4. **文献名称**: "Peroxiredoxin 2 regulates inflammatory signaling in macrophages via modulation of NF-κB activity"
**作者**: Rhee, S.G. et al.
**摘要**: 通过Western blot和免疫沉淀(使用PRDX2抗体)，发现PRDX2通过调控NF-κB信号通路抑制巨噬细胞炎症反应，揭示了其在先天免疫中的新功能。
*注：以上文献为示例性质，具体内容需根据实际发表论文调整。建议通过PubMed或Web of Science以“Peroxiredoxin 2 AND antibody”为关键词检索最新文献。*
Peroxiredoxin 2 (PRDX2) is a member of the peroxiredoxin family of antioxidant enzymes that play a critical role in cellular redox homeostasis by reducing reactive oxygen species (ROS), particularly hydrogen peroxide. It functions as a peroxidatic cysteine-dependent peroxidase, utilizing thioredoxin as an electron donor to neutralize oxidative stress and protect cellular components from damage. PRDX2 is ubiquitously expressed, with high levels in erythrocytes, neurons, and other tissues susceptible to oxidative injury. Beyond its antioxidant activity, PRDX2 participates in redox signaling, regulates cell proliferation, apoptosis, and inflammation, and interacts with various proteins to modulate pathways linked to cancer, neurodegeneration, and aging.
Antibodies targeting PRDX2 are essential tools for studying its expression, localization, and function in biological systems. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to quantify protein levels in disease models or assess tissue-specific distribution. Research involving PRDX2 antibodies has highlighted its dual role: while it acts as a tumor suppressor by curbing ROS-driven genomic instability, its overexpression in certain cancers is associated with chemoresistance and poor prognosis. Additionally, PRDX2 antibodies aid in exploring its neuroprotective effects in conditions like Alzheimer’s and Parkinson’s diseases, where oxidative stress is a key contributor. These studies underscore PRDX2’s potential as a therapeutic target or diagnostic biomarker in oxidative stress-related pathologies.
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