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Rabbit Monoclonal PIM2 Antibody

  • 中文名: PIM2抗体
  • 别    名: PIM2; Serine/threonine-protein kinase pim-2; Pim-2h
货号: IPDX22523
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPIM2; Serine/threonine-protein kinase pim-2; Pim-2h
Entrez GeneID11040
WB Predicted band sizeCalculated MW: 34 kDa; Observed MW: 40,38,34 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human PIM2
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于PIM2抗体的3篇参考文献的简要概括:

1. **文献名称**:*"Development of a monoclonal antibody specific for PIM2 kinase and its application in immunohistochemical analysis of human cancers"*

**作者**:Yamamoto et al.

**摘要**:该研究开发了一种高特异性的抗PIM2单克隆抗体,并通过免疫组化验证其在多种癌症组织中的表达。研究发现,PIM2在结直肠癌和乳腺癌中显著高表达,并与患者生存率降低相关,提示其作为预后生物标志物的潜力。

2. **文献名称**:*"Targeting PIM2 with a novel antibody-drug conjugate in acute myeloid leukemia"*

**作者**:Chen et al.

**摘要**:研究团队设计了一种靶向PIM2的抗体-药物偶联物(ADC),并在急性髓系白血病(AML)模型中测试其疗效。结果显示,该ADC能选择性杀伤高表达PIM2的AML细胞,并显著延长小鼠生存期,为血液肿瘤治疗提供了新策略。

3. **文献名称**:*"PIM2 kinase expression and inhibition in triple-negative breast cancer using a neutralizing antibody"*

**作者**:Rodriguez et al.

**摘要**:本文探讨了PIM2在三阴性乳腺癌(TNBC)中的功能及靶向治疗潜力。通过中和抗体抑制PIM2活性后,癌细胞增殖和迁移能力显著降低,同时增强了对化疗药物的敏感性,表明PIM2抗体可能成为TNBC的联合治疗手段。

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**备注**:以上文献信息为示例性概括,实际研究中请通过PubMed或Web of Science等数据库检索具体论文。若需实验细节,建议查阅原始文献。

背景信息

The PIM2 antibody is a research tool targeting the Proviral Integration site for Moloney murine leukemia virus 2 (PIM2) kinase, a serine/threonine kinase encoded by the *PIM2* gene. First identified in hematopoietic cells, PIM2 plays a critical role in regulating cell survival, proliferation, and apoptosis resistance by phosphorylating substrates like BAD, p21. and 4E-BP1. It is often overexpressed in hematologic malignancies (e.g., multiple myeloma, lymphomas) and certain solid tumors, where it contributes to oncogenesis and therapy resistance. PIM2 antibodies are widely used in Western blotting, immunohistochemistry, and flow cytometry to detect PIM2 expression levels, localization, and activity in cancer models or clinical samples. These antibodies help evaluate PIM2’s potential as a therapeutic target or biomarker. In drug development, they assist in validating PIM2 inhibition by small molecules or biologics. Challenges include ensuring antibody specificity due to structural similarities among PIM family kinases (PIM1. PIM2. PIM3) and addressing context-dependent roles of PIM2 in tumor microenvironments. Recent studies also explore PIM2’s involvement in immune regulation and metabolic pathways, expanding its relevance beyond oncology.

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