WB | 1/500-1/1000 | Human,Mouse,Rat |
IF | 1/20 | Human,Mouse,Rat |
IHC | 咨询技术 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | PIM2; Serine/threonine-protein kinase pim-2; Pim-2h |
Entrez GeneID | 11040 |
WB Predicted band size | Calculated MW: 34 kDa; Observed MW: 40,38,34 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | A synthetic peptide of human PIM2 |
Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于PIM2抗体的3篇参考文献的简要概括:
1. **文献名称**:*"Development of a monoclonal antibody specific for PIM2 kinase and its application in immunohistochemical analysis of human cancers"*
**作者**:Yamamoto et al.
**摘要**:该研究开发了一种高特异性的抗PIM2单克隆抗体,并通过免疫组化验证其在多种癌症组织中的表达。研究发现,PIM2在结直肠癌和乳腺癌中显著高表达,并与患者生存率降低相关,提示其作为预后生物标志物的潜力。
2. **文献名称**:*"Targeting PIM2 with a novel antibody-drug conjugate in acute myeloid leukemia"*
**作者**:Chen et al.
**摘要**:研究团队设计了一种靶向PIM2的抗体-药物偶联物(ADC),并在急性髓系白血病(AML)模型中测试其疗效。结果显示,该ADC能选择性杀伤高表达PIM2的AML细胞,并显著延长小鼠生存期,为血液肿瘤治疗提供了新策略。
3. **文献名称**:*"PIM2 kinase expression and inhibition in triple-negative breast cancer using a neutralizing antibody"*
**作者**:Rodriguez et al.
**摘要**:本文探讨了PIM2在三阴性乳腺癌(TNBC)中的功能及靶向治疗潜力。通过中和抗体抑制PIM2活性后,癌细胞增殖和迁移能力显著降低,同时增强了对化疗药物的敏感性,表明PIM2抗体可能成为TNBC的联合治疗手段。
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**备注**:以上文献信息为示例性概括,实际研究中请通过PubMed或Web of Science等数据库检索具体论文。若需实验细节,建议查阅原始文献。
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