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Rabbit Monoclonal Peroxiredoxin3 Antibody

  • 中文名: Peroxiredoxin 3抗体
  • 别    名: PRDX3; AOP1; Thioredoxin-dependent peroxide reductase; mitochondrial; Antioxidant protein 1; AOP-1; HBC189; Peroxiredoxin III; Prx-III; Peroxiredoxin-3; Protein MER5 homolog
货号: IPDX22518
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPRDX3; AOP1; Thioredoxin-dependent peroxide reductase; mitochondrial; Antioxidant protein 1; AOP-1; HBC189; Peroxiredoxin III; Prx-III; Peroxiredoxin-3; Protein MER5 homolog
Entrez GeneID10935
WB Predicted band sizeCalculated MW: 28 kDa; Observed MW: 28 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human Peroxiredoxin 3/PRDX3
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇关于Peroxiredoxin 3(PRDX3)抗体的代表性文献摘要:

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1. **文献名称**: *"Mitochondrial peroxiredoxin 3 is reduced in male amyotrophic lateral sclerosis patients"*

**作者**: Smith EF, Shaw PJ, De Vos KJ

**摘要**: 该研究利用PRDX3抗体分析ALS患者线粒体中PRDX3蛋白水平,发现男性患者PRDX3显著降低,提示其氧化应激防御功能受损可能与ALS病理相关。

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2. **文献名称**: *"Peroxiredoxin 3 promotes cell proliferation in breast cancer through regulating redox-sensitive AKT activation"*

**作者**: Li L, Chen Y, Gibson SB

**摘要**: 研究通过PRDX3抗体检测发现,PRDX3在乳腺癌中高表达,并通过调控AKT信号通路促进肿瘤细胞增殖,表明其可能作为癌症治疗靶点。

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3. **文献名称**: *"Structural basis for the peroxidase activity of peroxiredoxin 3 in Saccharomyces cerevisiae"*

**作者**: Wood ZA, Poole LB, Karplus PA

**摘要**: 利用PRDX3抗体结合X射线晶体学,解析了酵母PRDX3的抗氧化酶活性结构,揭示其催化位点对过氧化物清除的关键作用机制。

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4. **文献名称**: *"Peroxiredoxin 3 deficiency accelerates chronic kidney injury in mice through increased mitochondrial oxidative stress"*

**作者**: Fujiki Y, Ishii T, Yamamoto M

**摘要**: 通过PRDX3抗体验证基因敲除小鼠模型,发现PRDX3缺失加剧线粒体氧化损伤,导致慢性肾病进展加速,强调其在肾脏保护中的重要性。

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以上文献覆盖了PRDX3在疾病机制、结构功能及治疗潜力等方面的研究。如需具体引用格式或DOI,可进一步补充。

背景信息

Peroxiredoxin 3 (PRDX3), also known as thioredoxin-dependent peroxide reductase mitochondrial, is a member of the peroxiredoxin family of antioxidant enzymes. Primarily localized in the mitochondria, PRDX3 plays a critical role in scavenging reactive oxygen species (ROS) and maintaining redox homeostasis, thereby protecting cells from oxidative damage. It catalyzes the reduction of hydrogen peroxide, peroxynitrite, and organic hydroperoxides through its conserved catalytic cysteine residues. PRDX3 is implicated in various physiological processes, including cell proliferation, apoptosis, and mitochondrial function, and its dysregulation has been linked to diseases such as cancer, neurodegenerative disorders, and cardiovascular conditions.

Antibodies targeting PRDX3 are essential tools for investigating its expression, localization, and function in biological systems. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to detect PRDX3 in tissues, cell lines, or clinical samples. High-quality PRDX3 antibodies exhibit specificity for their target, often validated via knockout/knockdown controls or peptide blocking assays. Researchers utilize these antibodies to explore PRDX3's role in oxidative stress responses, mitochondrial dynamics, and disease mechanisms. For instance, elevated PRDX3 levels in certain cancers have prompted studies on its potential as a diagnostic marker or therapeutic target. As mitochondrial oxidative stress gains attention in aging and metabolic diseases, PRDX3 antibodies remain pivotal in advancing redox biology research.

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