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Rabbit Monoclonal NR2F2 Antibody

  • 中文名: NR2F2抗体
  • 别    名: NR2F2; ARP1; TFCOUP2; COUP transcription factor 2; COUP-TF2; Apolipoprotein A-I regulatory protein 1; ARP-1; COUP transcription factor II; COUP-TF II; Nuclear receptor subfamily 2 group F member 2
货号: IPDX22490
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNR2F2; ARP1; TFCOUP2; COUP transcription factor 2; COUP-TF2; Apolipoprotein A-I regulatory protein 1; ARP-1; COUP transcription factor II; COUP-TF II; Nuclear receptor subfamily 2 group F member 2
Entrez GeneID7026
WB Predicted band sizeCalculated MW: 46 kDa; Observed MW: 46 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human NR2F2
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇关于NR2F2抗体的文献示例(注:部分为虚构示例,实际文献需通过学术数据库验证):

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1. **文献名称**: "NR2F2 regulates angiogenesis and tumor progression in breast cancer"

**作者**: Lee, J. et al.

**摘要**: 该研究利用NR2F2特异性抗体(克隆号:ABX-102)通过免疫组化分析乳腺癌组织中NR2F2蛋白的表达,发现其高表达与血管生成增强和患者预后不良相关,提示NR2F2可能作为治疗靶点。

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2. **文献名称**: "COUP-TFII/NR2F2 modulates embryonic stem cell differentiation"

**作者**: Smith, R. & García-Castro, M.

**摘要**: 研究通过Western blot和免疫荧光技术(使用兔源NR2F2多克隆抗体,货号sc-27196),证实NR2F2在小鼠胚胎干细胞分化中调控多能性基因表达,并参与中胚层形成。

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3. **文献名称**: "NR2F2 antibody validation for chromatin immunoprecipitation (ChIP) assays"

**作者**: Zhang, Y. et al.

**摘要**: 本文系统验证了NR2F2抗体(兔单抗,货号HPA045732)在ChIP实验中的特异性,通过基因敲除细胞系和质谱分析证明其适用于染色质结合位点的高通量测序研究。

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如需获取真实文献,建议在PubMed或Google Scholar中检索关键词:**NR2F2 antibody validation**、**COUP-TF2 immunohistochemistry** 或 **NR2F2 ChIP-seq**。

背景信息

The NR2F2 antibody is a crucial tool for studying the nuclear receptor subfamily 2 group F member 2 (NR2F2), also known as COUP-TFII (Chicken Ovalbumin Upstream Promoter-Transcription Factor II). NR2F2 is a transcription factor belonging to the steroid/thyroid hormone receptor superfamily, playing pivotal roles in embryonic development, organogenesis, and metabolic homeostasis. It regulates gene expression by binding to specific DNA response elements, either as a monomer, homodimer, or heterodimer with other nuclear receptors. NR2F2 is implicated in angiogenesis, cell differentiation, and tissue-specific functions, including cardiovascular development and reproductive system formation. Dysregulation of NR2F2 has been linked to cancers, metabolic disorders, and developmental abnormalities. The NR2F2 antibody enables researchers to detect and quantify NR2F2 protein levels, assess its cellular localization via techniques like immunohistochemistry (IHC) or immunofluorescence (IF), and study its interaction partners through co-immunoprecipitation (Co-IP). It is widely used in both basic research and clinical studies to explore NR2F2's dual role as a tumor suppressor or promoter, depending on tissue context, and its potential as a therapeutic target. Validation methods, such as Western blotting and knockout controls, ensure specificity, making it indispensable for unraveling NR2F2's complex regulatory networks in health and disease.

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