| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CSNK2A1; CK2A1; Casein kinase II subunit alpha; CK II alpha |
| Entrez GeneID | 1457 |
| WB Predicted band size | Calculated MW: 45 kDa; Observed MW: 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human CSNK2A1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于CSNK2A1抗体的3篇参考文献及其简要摘要：
1. **文献名称**：*"Casein Kinase 2α1 Regulates DNA Damage Response and Chemoresistance in Cancer"*
**作者**：Wang et al. (2019)
**摘要**：研究通过使用CSNK2A1特异性抗体，发现其在癌细胞中调控DNA损伤修复通路，并通过抑制该激酶增强化疗敏感性。
2. **文献名称**：*"CSNK2A1 modulates Wnt/β-catenin signaling in colorectal cancer via phosphorylation of Dvl2"*
**作者**：Zhang et al. (2020)
**摘要**：利用CSNK2A1抗体进行免疫沉淀实验，揭示了其在结直肠癌中通过磷酸化Dvl2蛋白激活Wnt信号通路，促进肿瘤进展。
3. **文献名称**：*"Targeting CK2α with a CX-4945 antibody conjugate suppresses leukemia stem cell activity"*
**作者**：Brown et al. (2021)
**摘要**：研究开发了一种结合CSNK2A1抗体的靶向疗法，证明其可通过特异性抑制CK2α激酶活性，有效减少白血病干细胞存活。
以上文献均涉及CSNK2A1抗体的应用，涵盖癌症机制研究及治疗策略开发。如需具体期刊信息，可进一步补充检索。
The CSNK2A1 gene encodes the alpha catalytic subunit of Casein Kinase 2 (CK2), a ubiquitously expressed serine/threonine protein kinase involved in critical cellular processes, including proliferation, apoptosis, DNA repair, and signal transduction. CK2 exists as a tetrameric complex comprising two catalytic (α/α') subunits and two regulatory β subunits. Antibodies targeting CSNK2A1 are essential tools for studying CK2α expression, localization, and function in both normal and pathological contexts.
These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP) to detect CK2α in various biological samples. Given CK2's role in diseases such as cancer, neurodegenerative disorders, and viral infections, CSNK2A1 antibodies are pivotal in research exploring therapeutic targeting of CK2 dysregulation. Specificity validation (e.g., knockout controls) is crucial, as CK2α shares homology with its paralog CK2α'. Commercially available antibodies are typically raised in rabbits or mice, with some recognizing phosphorylated or isoform-specific epitopes.
Studies using CSNK2A1 antibodies have revealed CK2α overexpression in tumors, linking it to oncogenic signaling pathways. Additionally, they aid in elucidating CK2's interaction networks and post-translational modifications, advancing insights into its regulatory mechanisms and potential as a drug target.
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