| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | REL |
| Entrez GeneID | 5966 |
| WB Predicted band size | Calculated MW: 69 kDa; Observed MW: 78 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human c-Rel |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于c-Rel抗体的示例性参考文献(内容为示例，建议通过学术数据库验证)：
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1. **"c-Rel is essential for B lymphocyte survival and cell cycle progression"**
*作者：N. Rice et al.*
摘要：研究通过c-Rel缺陷小鼠模型，揭示了c-Rel在B细胞存活和周期调控中的关键作用，其缺失导致B细胞凋亡增加及免疫应答减弱。
2. **"Selective inhibition of c-Rel signaling suppresses inflammatory responses"**
*作者：M.R. Gold et al.*
摘要：开发了一种小分子抑制剂靶向c-Rel，在类风湿性关节炎模型中显著降低炎症因子水平，证实c-Rel作为治疗自身免疫疾病的潜在靶点。
3. **"c-Rel expression in diffuse large B-cell lymphoma: prognostic implications"**
*作者：L. Staudt et al.*
摘要：通过免疫组化分析c-Rel在淋巴瘤中的表达，发现高表达与患者不良预后相关，提示其可作为癌症生物标志物。
4. **"Antibody-specific detection of c-Rel in NF-κB signaling complexes"**
*作者：R. Sivakumar et al.*
摘要：比较多种c-Rel抗体的特异性，优化ChIP实验条件，为研究c-Rel在NF-κB通路中的DNA结合活性提供方法学参考。
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建议通过**PubMed**或**Google Scholar**检索真实文献，使用关键词“c-Rel antibody”、“c-Rel NF-kB”或“c-Rel immune function”。
The c-Rel antibody is a crucial tool for studying the c-Rel protein, a member of the NF-κB transcription factor family, which plays pivotal roles in immune responses, inflammation, and cell survival. c-Rel, encoded by the *REL* gene, is characterized by a conserved N-terminal Rel homology domain (RHD) responsible for DNA binding and dimerization, and a C-terminal transactivation domain (TAD) that regulates target gene expression. Unlike other NF-κB members, c-Rel is primarily expressed in immune cells, including lymphocytes and macrophages, where it regulates cytokine production (e.g., IL-2. TNF-α) and cell proliferation. Its activity is tightly controlled by inhibitory IκB proteins and upstream signaling pathways, such as the T-cell receptor (TCR) and Toll-like receptor (TLR) cascades.
c-Rel-specific antibodies enable researchers to detect its expression, nuclear translocation, and interaction partners via techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Dysregulation of c-Rel is linked to autoimmune diseases (e.g., rheumatoid arthritis), chronic inflammation, and cancers (e.g., lymphoma), making its antibody a vital reagent for mechanistic and therapeutic studies. Commercial c-Rel antibodies are typically raised in rabbits or mice, targeting epitopes within the RHD or TAD, and validated for specificity across human and murine models. Recent studies also explore c-Rel's role in Treg cell function and cancer immunotherapy resistance, highlighting its expanding biomedical relevance.
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