| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AK3; AK 4; AK3L1; AK3L2 |
| Entrez GeneID | 205 |
| WB Predicted band size | Calculated MW: 25 kDa; Observed MW: 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human AK3L1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于AK3L1抗体的假设性参考文献示例(注：实际文献可能需要通过学术数据库验证，以下内容仅供参考)：
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1. **文献名称**：*AK3L1 Expression in Colorectal Cancer and Its Prognostic Significance*
**作者**：Zhang Y, et al. (2015)
**摘要**：本研究利用兔源多克隆AK3L1抗体，通过免疫组化分析结直肠癌组织中AK3L1蛋白表达水平，发现其表达下调与患者生存率降低相关，提示AK3L1可能作为肿瘤抑制因子发挥作用。
2. **文献名称**：*Development of a Monoclonal Antibody for Human AK3L1 and Its Application in Mitochondrial Localization Studies*
**作者**：Liu X, et al. (2020)
**摘要**：报道了一种特异性小鼠单克隆AK3L1抗体的开发，并验证其在线粒体定位分析中的有效性。研究发现AK3L1通过调控AMP/ATP代谢影响细胞凋亡。
3. **文献名称**：*AK3L1 Regulates Energy Metabolism in Cardiomyocytes: Insights from Antibody-Based Functional Inhibition*
**作者**：Wang H, et al. (2018)
**摘要**：通过AK3L1抗体介导的功能抑制实验，揭示了AK3L1在心肌细胞线粒体能量代谢中的关键作用，为代谢相关心脏病机制提供新视角。
4. **文献名称**：*Validation of AK3L1 Antibody Specificity in Western Blot and Immunoprecipitation Assays*
**作者**：Smith J, et al. (2017)
**摘要**：系统评估了多种商业AK3L1抗体的特异性，筛选出适用于Western Blot和IP实验的高效抗体，为后续功能研究提供可靠工具。
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**提示**：以上内容为模拟示例，实际研究中请通过PubMed、Google Scholar等平台检索关键词(如“AK3L1 antibody”“adenylate kinase 3-like 1”)获取准确文献。若目标蛋白为AK4(即AK3L1别名)，可调整关键词扩大检索范围。
The AK3L1 (Adenylate Kinase 3-Like 1) antibody targets a protein encoded by the AK4 gene, which belongs to the adenylate kinase family. Adenylate kinases are crucial for maintaining cellular energy homeostasis by catalyzing the reversible transfer of phosphate groups between nucleotides (e.g., ATP, ADP, AMP). AK3L1. also known as AK4. localizes to mitochondria and plays a role in energy metabolism, particularly under hypoxic conditions. It is implicated in regulating nucleotide balance, influencing processes like cell proliferation, apoptosis, and stress adaptation.
Research suggests AK3L1/AK4 expression is linked to cancer progression, as it is often upregulated in tumors, promoting metabolic reprogramming and chemoresistance. Its mitochondrial localization underscores its role in oxidative phosphorylation and reactive oxygen species (ROS) management. The AK3L1 antibody is widely used in studies to detect protein expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It helps elucidate AK4's functional mechanisms in diseases, including metabolic disorders and cancer, offering potential as a therapeutic or diagnostic target. This antibody is essential for exploring mitochondrial energy dynamics and cellular stress responses.
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