| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | adenylate kinase 2; ADK2; AK 2 |
| Entrez GeneID | 204 |
| WB Predicted band size | Calculated MW: 26 kDa; Observed MW: 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human AK2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇与AK2抗体相关的文献示例(注：文献信息为模拟虚构，仅供格式参考)：
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1. **文献名称**：*AK2 deficiency causes human immunodeficiency through mitochondrial apoptosis*
**作者**：Pannicke U. et al.
**摘要**：本研究揭示了AK2基因突变导致严重联合免疫缺陷(SCID)的机制。通过AK2特异性抗体检测，发现患者淋巴细胞中AK2蛋白缺失，引发线粒体依赖性细胞凋亡，阐明了AK2在免疫细胞存活中的关键作用。
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2. **文献名称**：*Adenylate kinase 2 as a biomarker in acute myeloid leukemia*
**作者**：Chen L. et al.
**摘要**：利用AK2抗体进行蛋白质组学分析，发现急性髓系白血病(AML)患者中AK2表达显著上调。实验表明AK2通过调控ATP代谢促进白血病细胞增殖，提示其作为潜在治疗靶点。
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3. **文献名称**：*Development of a monoclonal antibody for AK2 subcellular localization studies*
**作者**：Tanaka R. et al.
**摘要**：报道了一种高特异性AK2单克隆抗体的开发，并通过免疫荧光和Western blot验证其在线粒体定位中的应用。该抗体为研究AK2在能量代谢和疾病中的功能提供了可靠工具。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“AK2 antibody”、“Adenylate Kinase 2”及具体研究领域(如免疫、癌症)。
**Background of AK2 Antibodies**
Adenylate kinase 2 (AK2) is a mitochondrial enzyme critical for cellular energy homeostasis, catalyzing the reversible transfer of phosphate groups between nucleotides (e.g., ATP, ADP, AMP). It plays a vital role in maintaining nucleotide balance, supporting processes like oxidative phosphorylation, cell proliferation, and apoptosis. AK2 is highly expressed in tissues with high energy demands, including the brain, heart, and immune cells.
AK2 dysfunction is linked to human diseases. Biallelic mutations in the *AK2* gene cause reticular dysgenesis (RD), a severe combined immunodeficiency (SCID) characterized by impaired lymphocyte and granulocyte development. RD underscores AK2's role in hematopoietic cell survival and mitochondrial metabolism. Additionally, aberrant AK2 expression is observed in cancers, such as leukemia and glioblastoma, where it may influence tumor progression and chemoresistance.
AK2 antibodies are essential tools for studying its expression, localization, and interactions in health and disease. They enable detection via techniques like Western blot, immunohistochemistry, and flow cytometry. Research using AK2 antibodies has advanced understanding of mitochondrial bioenergetics, immune cell development, and cancer biology. Furthermore, these antibodies hold potential for diagnostic applications, such as identifying RD or profiling AK2 in malignancies. Their development continues to support therapeutic exploration, including targeting AK2 in metabolic disorders or oncology.
In summary, AK2 antibodies serve as pivotal reagents in unraveling the enzyme's multifaceted roles and translational implications.
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