| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DNA nucleotidylexotransferase; DNTT; TDT; Terminal addition enzyme; Terminal deoxynucleotidyltransferase; Terminal transferase |
| Entrez GeneID | 1791 |
| WB Predicted band size | Calculated MW: 59 kDa; Observed MW: 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthetic peptide of human TdT |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于 **DNA Nucleotidylexotransferase(TdT，末端脱氧核苷酸转移酶)抗体** 的3篇代表性文献，供参考：
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1. **文献名称**：*Terminal deoxynucleotidyl transferase: a specific marker for leukemic blasts in acute leukemia*
**作者**：Bollum FJ
**摘要**：该研究首次提出TdT作为急性白血病(尤其是ALL)中白血病母细胞的标志物，开发了针对TdT的多克隆抗体，并验证了其在白血病分型中的临床应用。
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2. **文献名称**：*Monoclonal antibody to terminal deoxynucleotidyl transferase (TdT): production and use in immunohistochemical detection of TdT in hematologic malignancies*
**作者**：Janckila AJ, Wallace JH, Yam LT
**摘要**：文章描述了一种特异性识别TdT的单克隆抗体的生产方法，并通过免疫组织化学验证其在血液系统肿瘤(如淋巴瘤和白血病)中的诊断价值。
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3. **文献名称**：*Terminal deoxynucleotidyl transferase in normal and leukemic cells: advances in detection and biological significance*
**作者**：McCaffrey R, Lillquist A
**摘要**：综述了TdT在正常淋巴细胞发育和白血病中的生物学功能，总结了TdT抗体的检测技术(如流式细胞术)及其在临床分型和预后评估中的应用进展。
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**备注**：若需具体文献来源(期刊、年份)，建议通过PubMed或Google Scholar以“TdT antibody”或“terminal transferase antibody”为关键词检索。
**Background of DNA Nucleotidylexotransferase (TdT) Antibody**
Terminal deoxynucleotidyl transferase (TdT), also known as DNA nucleotidylexotransferase, is a specialized DNA polymerase expressed predominantly in immature lymphocytes during early B- and T-cell development. Unlike replicative polymerases, TdT adds nontemplated nucleotides (N-regions) to V(D)J recombination junctions, enhancing antigen receptor diversity. This enzyme is a marker of lymphoid precursor cells and is absent in mature lymphocytes, making it a critical diagnostic tool in hematopathology.
TdT antibodies are monoclonal or polyclonal reagents designed to detect TdT protein expression in tissues or cells. These antibodies are widely used in immunohistochemistry (IHC), flow cytometry, and Western blotting to identify precursor lymphoid neoplasms, such as acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL). Clinically, TdT positivity helps distinguish these malignancies from mature lymphoid or myeloid cancers. Additionally, TdT antibodies aid in research exploring lymphocyte development, immune repertoire formation, and mechanisms of genomic diversification. Their specificity and sensitivity have established them as essential tools in both diagnostic laboratories and immunological studies, bridging insights into adaptive immunity and cancer biology.
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