| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SII; TCEA; TF2S; GTF2S; TFIIS |
| Entrez GeneID | 6917 |
| WB Predicted band size | Calculated MW: 34 kDa; Observed MW: 34 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human TCEA1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于TCEA1抗体的虚构参考文献示例(仅供格式参考，非真实文献)：
1. **文献名称**: *TCEA1 Autoantibodies as a Novel Biomarker in Pancreatic Cancer*
**作者**: Smith J, et al. (2018)
**摘要**: 研究报道了TCEA1抗体在胰腺癌患者血清中的高表达，提示其可能作为早期诊断的潜在生物标志物，并探讨了其与肿瘤进展的相关性。
2. **文献名称**: *TCEA1 Antibody-Mediated Transcriptional Dysregulation in Autoimmune Diseases*
**作者**: Lee S, et al. (2020)
**摘要**: 该研究发现TCEA1自身抗体在类风湿性关节炎患者中的异常表达，可能通过干扰RNA聚合酶II的延伸功能，参与自身免疫反应的病理机制。
3. **文献名称**: *Functional Characterization of Anti-TCEA1 Antibodies in Gene Expression Regulation*
**作者**: Chen X, et al. (2019)
**摘要**: 通过体外实验揭示了TCEA1抗体对转录延伸复合体的抑制作用，导致靶基因表达下调，为癌症治疗中抗体靶向策略提供理论依据。
4. **文献名称**: *TCEA1 Autoantibodies in Non-Small Cell Lung Cancer: Clinical Implications*
**作者**: Garcia R, et al. (2021)
**摘要**: 分析了TCEA1抗体在非小细胞肺癌患者中的预后价值，发现其高滴度与化疗耐药性和生存率降低显著相关。
注：以上文献为模拟示例，实际研究中请通过PubMed或Web of Science等平台检索真实发表的论文。
The TCEA1 antibody targets the Transcription Elongation Factor A1 (TCEA1), a protein encoded by the TCEA1 gene in humans. TCEA1. also known as SII, is a critical component of the RNA polymerase II transcription elongation complex. It facilitates transcriptional elongation by preventing RNA polymerase II stalling, enhancing the processivity of the enzyme, and ensuring accurate RNA synthesis. This protein plays a role in regulating gene expression and is implicated in various cellular processes, including development, differentiation, and stress responses.
Antibodies against TCEA1 are valuable tools in molecular and cellular research, enabling the detection and quantification of TCEA1 in tissues or cultured cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies involving TCEA1 antibodies have contributed to understanding its interaction with transcriptional machinery, its role in diseases such as cancer (where altered expression may influence tumor progression), and potential links to neurological disorders. Researchers also utilize these antibodies to explore TCEA1’s post-translational modifications and its functional dynamics in DNA repair or replication stress scenarios. As a biomarker or therapeutic target, TCEA1 remains an area of active investigation in both basic and clinical research contexts.
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