| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ATG24B |
| Entrez GeneID | 8723 |
| WB Predicted band size | Calculated MW: 52 kDa; Observed MW: 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human SNX4 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇涉及SNX4抗体的文献摘要信息(注：以下内容为基于领域知识的模拟示例，实际文献需通过学术数据库验证)：
1. **文献名称**：*"SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport"*
**作者**：Ma M et al.
**摘要**：本研究利用SNX4特异性抗体进行免疫沉淀和免疫荧光实验，揭示了SNX4在转铁蛋白受体(TfnR)的内体分选过程中与动力蛋白协同作用的机制，证明SNX4缺失导致内体运输障碍。
2. **文献名称**：*"Sorting nexin 4 regulates amyloid precursor protein trafficking and processing in Alzheimer's disease models"*
**作者**：Chen Y et al.
**摘要**：通过Western blot和免疫组化(使用SNX4抗体)，研究发现SNX4通过调控APP蛋白的运输影响β淀粉样蛋白生成，提示SNX4在阿尔茨海默病病理中的潜在作用。
3. **文献名称**：*"Characterization of a novel monoclonal antibody against SNX4 reveals its role in autophagy"*
**作者**：Suzuki K et al.
**摘要**：文章报道了一种新型SNX4单克隆抗体的开发与验证，并利用该抗体证实SNX4通过参与自噬体形成阶段调控细胞自噬过程。
4. **文献名称**：*"SNX4 interacts with the HER2 receptor to modulate its endosomal sorting in breast cancer cells"*
**作者**：Wang L et al.
**摘要**：研究通过共聚焦显微术(使用SNX4抗体标记)和蛋白互作分析，发现SNX4与HER2受体结合并影响其在乳腺癌细胞中的内吞循环，为靶向治疗提供新思路。
(建议通过PubMed或Google Scholar以“SNX4 antibody”或“Sorting Nexin 4”为关键词检索最新文献获取准确信息。)
The SNX4 (Sorting Nexin 4) antibody is a crucial tool for studying the function and localization of SNX4. a member of the sorting nexin protein family. Sorting nexins are characterized by their phosphoinositide-binding PX domains, which facilitate membrane association and participation in intracellular trafficking processes. SNX4 specifically regulates endosomal sorting, membrane remodeling, and autophagy by interacting with components of the retromer complex and other trafficking machinery. It plays a role in recycling transmembrane proteins (e.g., receptors, transporters) from endosomes to the Golgi or plasma membrane, ensuring cellular homeostasis.
Antibodies targeting SNX4 are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to analyze its expression, subcellular distribution, and protein-protein interactions. Research involving SNX4 antibodies has highlighted its involvement in neurodegenerative diseases (e.g., Alzheimer’s) and cancer, where disrupted membrane trafficking contributes to pathogenesis. These antibodies also help investigate SNX4’s interplay with homologs like SNX1/SNX2 or autophagy-related proteins (e.g., ATG9A). Validation of SNX4 antibodies typically includes knockout cell line controls to ensure specificity. As SNX4’s role in organelle dynamics gains attention, such antibodies remain vital for dissecting its contributions to cellular physiology and disease mechanisms.
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