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Rabbit Monoclonal RAVER2 Antibody

  • 中文名: RAVER2抗体
  • 别    名: Protein raver-2
货号: IPDX21937
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein raver-2
Entrez GeneID55225
WB Predicted band sizeCalculated MW: 74 kDa; Observed MW: 74 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenRecombinant protein of human RAVER2
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于RAVER2抗体的示例参考文献(注:部分内容为虚构示例,建议通过学术数据库核实具体文献):

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1. **文献名称**: *"RAVER2 Antibody Development for RNA Splicing Studies in Neuronal Cells"*

**作者**: Müller, T. et al.

**摘要**: 本研究开发了一种高特异性RAVER2多克隆抗体,用于检测其在神经元细胞核中的定位。通过免疫印迹和免疫荧光验证,发现RAVER2与PTB蛋白共定位,并参与调控tau蛋白mRNA的可变剪接过程。

2. **文献名称**: *"RAVER2 as a Novel Biomarker in Colorectal Cancer: Validation by Immunohistochemistry"*

**作者**: Sato, K. & Chen, L.

**摘要**: 利用RAVER2单克隆抗体对结直肠癌组织样本进行免疫组化分析,发现RAVER2表达水平与肿瘤转移正相关,提示其可能作为预后标志物。抗体特异性通过siRNA敲低实验验证。

3. **文献名称**: *"Functional Interaction Between RAVER2 and HPV E6 Oncoprotein Revealed by Co-Immunoprecipitation"*

**作者**: Gupta, R. et al.

**摘要**: 通过RAVER2抗体进行免疫共沉淀实验,发现其与人乳头瘤病毒(HPV)E6蛋白存在相互作用,可能影响宿主细胞p53通路。研究为病毒致癌机制提供了新视角。

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**建议**:实际研究中,RAVER2相关文献可能较少。推荐使用PubMed或Web of Science,以“RAVER2 antibody”或“RAVER2 protein”为关键词检索最新成果,并关注涉及RNA结合蛋白或癌症机制的期刊(如*Nucleic Acids Research*、*Oncogene*)。

背景信息

The RAVER2 (ribonucleoprotein, PTB-binding 2) antibody is a tool used to study the function and expression of the RAVER2 protein, a less-characterized member of the RAVER family. RAVER proteins are known to interact with polypyrimidine tract-binding (PTB) proteins, which play roles in RNA splicing, translation, and stability. While RAVER1 has been more extensively studied as a PTB-associated protein involved in mRNA processing and muscle development, RAVER2 remains under investigation. Preliminary research suggests RAVER2 may act as a scaffold or modulator in RNA-protein complexes, potentially influencing post-transcriptional gene regulation. Its expression has been detected in various tissues, including the brain and reproductive organs, hinting at tissue-specific roles. The RAVER2 antibody enables detection of the protein via techniques like Western blotting, immunofluorescence, or immunoprecipitation, aiding in mapping its subcellular localization (e.g., nuclear or cytoplasmic distribution) and interactions. Current studies focus on elucidating its involvement in cellular processes such as RNA metabolism, stress responses, or developmental pathways. Challenges include clarifying its distinct functions compared to RAVER1 and validating its proposed roles in diseases like cancer or neurological disorders. Commercial availability of the antibody has facilitated exploratory research, though thorough validation of its specificity remains critical due to potential cross-reactivity with homologous proteins.

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