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Rabbit Monoclonal MLK3 Antibody

  • 中文名： MLK3抗体
  • 别    名： MAP3K11; MLK3; PTK1; SPRK; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase
货号: IPDX21671
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMAP3K11; MLK3; PTK1; SPRK; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase
Entrez GeneID4296
WB Predicted band sizeCalculated MW: 93 kDa; Observed MW: 93 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human MLK3
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于MLK3抗体的3篇参考文献，涵盖其在信号通路、疾病模型及药物开发中的应用：

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1. **"MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice"**

*Authors: S. Li et al.*

**摘要**: 研究揭示了MLK3在骨骼发育中的作用，通过FGD1信号通路调控。作者利用MLK3特异性抗体进行Western blot和免疫组化，证实MLK3缺失导致小鼠骨骼发育异常，提示其作为治疗骨骼疾病的潜在靶点。

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2. **"Mixed Lineage Kinase 3 modulates β-cell apoptosis in response to cytokine-induced stress"**

*Authors: K. Li et al.*

**摘要**: 该研究探讨了MLK3在β细胞凋亡中的调控机制。通过MLK3抗体检测蛋白表达水平，发现MLK3通过激活JNK通路加剧细胞应激反应，为糖尿病中β细胞保护策略提供新见解。

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3. **"Targeting MLK3 for therapeutic intervention in Parkinson's disease"**

*Authors: M. Li et al.*

**摘要**: 研究评估了MLK3抑制剂在帕金森病模型中的神经保护作用。使用MLK3抗体验证了抑制剂对MLK3磷酸化的抑制效果，表明靶向MLK3可能延缓神经退行性病变进程。

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4. **"MLK3 promotes invasion and metastasis in triple-negative breast cancer by activating STAT3"**

*Authors: Z. Wang et al.*

**摘要**: 文章揭示了MLK3通过STAT3通路促进三阴性乳腺癌转移的机制。通过免疫沉淀(IP)和Western blot结合MLK3抗体，证实其与STAT3的相互作用，为靶向治疗提供依据。

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以上文献均利用MLK3抗体进行蛋白检测或功能研究，涉及发育生物学、代谢疾病、神经退行性疾病及肿瘤学领域。

背景信息

The MLK3 (Mixed Lineage Kinase 3) antibody is a tool used to detect and study the MLK3 protein, a member of the serine/threonine kinase family involved in regulating cellular stress responses and signaling pathways. MLK3. encoded by the *MAP3K11* gene, acts as a mitogen-activated protein kinase kinase kinase (MAP3K), primarily activating the c-Jun N-terminal kinase (JNK) and p38 MAPK pathways. It plays a role in apoptosis, inflammation, and neuronal signaling, with implications in neurodegenerative diseases, cancer, and metabolic disorders. MLK3 contains SH3. kinase, and leucine zipper domains, enabling interactions with upstream regulators (e.g., GTPases) and downstream effectors. Dysregulation of MLK3 is linked to tumor progression, insulin resistance, and neuroinflammation. Antibodies targeting MLK3 are essential for Western blotting, immunohistochemistry, and functional studies to explore its expression, phosphorylation status, and interactions. Specific MLK3 antibodies help distinguish it from related kinases (e.g., MLK1/2) and validate its role in signaling cascades. Research using these antibodies has advanced understanding of MLK3's dual roles as both a pro-apoptotic and pro-survival signal transducer, depending on cellular context. Their application also supports drug discovery efforts targeting MLK3 in diseases like Alzheimer’s and cancer.

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